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• W1953034948 abstract "ABSTRACT A genetic locus for a cytolethal distending toxin (CDT) was identified in a polymorphic region of the chromosome of Actinobacillus actinomycetemcomitans , a predominant oral pathogen. The locus was comprised of three open reading frames (ORFs) that had significant amino acid sequence similarity and more than 90% sequence identity to the cdtABC genes of some pathogenic Escherichia coli strains and Haemophilus ducreyi , respectively. Sonic extracts from recombinant E. coli , containing the A. actinomycetemcomitans ORFs, caused the distension and killing of Chinese hamster ovary cells characteristic of a CDT. Monoclonal antibodies made reactive with the CdtA, CdtB, and CdtC proteins of H. ducreyi recognized the corresponding gene products from the recombinant strain. CDT-like activities were no longer expressed by the recombinant strain when an ΩKan-2 interposon was inserted into the cdtA and cdtB genes. Expression of the CDT-like activities in A. actinomycetemcomitans was strain specific. Naturally occurring expression-negative strains had large deletions within the region of the cdt locus. The cdtABC genes were flanked by an ORF (virulence plasmid protein), a partial ORF (integrase), and DNA sequences (bacteriophage integration site) characteristic of virulence-associated regions. These results provide evidence for a functional CDT in a human oral pathogen." @default.
• W1953034948 created "2016-06-24" @default.
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• W1953034948 date "1999-03-01" @default.
• W1953034948 modified "2023-10-14" @default.
• W1953034948 title "Identification of a Cytolethal Distending Toxin Gene Locus and Features of a Virulence-Associated Region in <i>Actinobacillus actinomycetemcomitans</i>" @default.
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• W1953034948 doi "https://doi.org/10.1128/iai.67.3.1227-1237.1999" @default.
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