Matches in SemOpenAlex for { <https://semopenalex.org/work/W1953648512> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W1953648512 abstract "In cases of breast cancer, the diagnoses of parenchymal brain metastases and leptomeningeal carcinomatosis are often delayed (1). New inexpensive biochemical diagnostic initiatives have suggested measurement of cytokeratin tumor markers in the cerebrospinal fluid (CSF) (2)(3). Each type of epithelial cell can be characterized by its cytokeratin polypeptide content because the expression pattern varies with the type of epithelium (4)(5)(6). Malignant epithelial tumors and their metastases maintain the cytokeratin expression typical for the tissue of origin (4)(7)(8). Cytokeratins 8, 18, and 19 are abundantly expressed in adenocarcinoma of the breast, only weakly expressed in epithelial cells of the choroid plexus, and not expressed in nerve, glial, ependymal, and meningeal cells (9). Because neither healthy nor malignant epithelial cells are known to secrete cytokeratins, how they appear in the CSF remains unexplained. Some authors have suggested that cytokeratins are released from the large fraction of dead and dying cells in growing tumors (5), whereas others have suggested that cytokeratins are markers of cell proliferation released during mitosis (10). In either case, release may indicate cell turnover in central nervous system (CNS) metastases from adenocarcinoma. Previous reports have addressed the diagnostic performance of the tissue polypeptide antigen (TPA) assay system in the CSF (2). The system uses polyclonal antibodies, and data indicate that they recognize the rod domain of the cytokeratin 8, 18, and 19 fragments; however, the exact structure of the binding epitope is unknown. Recently, another cytokeratin-based assay system that measures tissue polypeptide-specific antigen (TPS) has become commercially available. The TPS …" @default.
- W1953648512 created "2016-06-24" @default.
- W1953648512 creator A5014762636 @default.
- W1953648512 creator A5088912710 @default.
- W1953648512 date "2001-05-01" @default.
- W1953648512 modified "2023-10-18" @default.
- W1953648512 title "Cerebrospinal Fluid Cytokeratins for Diagnosis of Patients with Central Nervous System Metastases from Breast Cancer" @default.
- W1953648512 cites W1956818913 @default.
- W1953648512 cites W2016693266 @default.
- W1953648512 cites W2091125427 @default.
- W1953648512 cites W2097789839 @default.
- W1953648512 cites W2106797584 @default.
- W1953648512 cites W2123967849 @default.
- W1953648512 cites W36858338 @default.
- W1953648512 doi "https://doi.org/10.1093/clinchem/47.5.948" @default.
- W1953648512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11325905" @default.
- W1953648512 hasPublicationYear "2001" @default.
- W1953648512 type Work @default.
- W1953648512 sameAs 1953648512 @default.
- W1953648512 citedByCount "2" @default.
- W1953648512 countsByYear W19536485122017 @default.
- W1953648512 crossrefType "journal-article" @default.
- W1953648512 hasAuthorship W1953648512A5014762636 @default.
- W1953648512 hasAuthorship W1953648512A5088912710 @default.
- W1953648512 hasBestOaLocation W19536485121 @default.
- W1953648512 hasConcept C121608353 @default.
- W1953648512 hasConcept C134018914 @default.
- W1953648512 hasConcept C142724271 @default.
- W1953648512 hasConcept C204232928 @default.
- W1953648512 hasConcept C2776538271 @default.
- W1953648512 hasConcept C2779012181 @default.
- W1953648512 hasConcept C2779651940 @default.
- W1953648512 hasConcept C2781182431 @default.
- W1953648512 hasConcept C529278444 @default.
- W1953648512 hasConcept C530470458 @default.
- W1953648512 hasConcept C54355233 @default.
- W1953648512 hasConcept C71924100 @default.
- W1953648512 hasConcept C86803240 @default.
- W1953648512 hasConceptScore W1953648512C121608353 @default.
- W1953648512 hasConceptScore W1953648512C134018914 @default.
- W1953648512 hasConceptScore W1953648512C142724271 @default.
- W1953648512 hasConceptScore W1953648512C204232928 @default.
- W1953648512 hasConceptScore W1953648512C2776538271 @default.
- W1953648512 hasConceptScore W1953648512C2779012181 @default.
- W1953648512 hasConceptScore W1953648512C2779651940 @default.
- W1953648512 hasConceptScore W1953648512C2781182431 @default.
- W1953648512 hasConceptScore W1953648512C529278444 @default.
- W1953648512 hasConceptScore W1953648512C530470458 @default.
- W1953648512 hasConceptScore W1953648512C54355233 @default.
- W1953648512 hasConceptScore W1953648512C71924100 @default.
- W1953648512 hasConceptScore W1953648512C86803240 @default.
- W1953648512 hasLocation W19536485121 @default.
- W1953648512 hasLocation W19536485122 @default.
- W1953648512 hasOpenAccess W1953648512 @default.
- W1953648512 hasPrimaryLocation W19536485121 @default.
- W1953648512 hasRelatedWork W1973828570 @default.
- W1953648512 hasRelatedWork W1974835982 @default.
- W1953648512 hasRelatedWork W1975551925 @default.
- W1953648512 hasRelatedWork W1977596209 @default.
- W1953648512 hasRelatedWork W1995255507 @default.
- W1953648512 hasRelatedWork W2006109790 @default.
- W1953648512 hasRelatedWork W2007253203 @default.
- W1953648512 hasRelatedWork W2045311508 @default.
- W1953648512 hasRelatedWork W2063967908 @default.
- W1953648512 hasRelatedWork W2064621607 @default.
- W1953648512 hasRelatedWork W2087084538 @default.
- W1953648512 hasRelatedWork W2094901034 @default.
- W1953648512 hasRelatedWork W2096687765 @default.
- W1953648512 hasRelatedWork W2114690717 @default.
- W1953648512 hasRelatedWork W2130143572 @default.
- W1953648512 hasRelatedWork W2157951753 @default.
- W1953648512 hasRelatedWork W2411207555 @default.
- W1953648512 hasRelatedWork W2431945996 @default.
- W1953648512 hasRelatedWork W2435366474 @default.
- W1953648512 hasRelatedWork W56887765 @default.
- W1953648512 isParatext "false" @default.
- W1953648512 isRetracted "false" @default.
- W1953648512 magId "1953648512" @default.
- W1953648512 workType "article" @default.