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- W195374014 abstract "Based on the Tritope Model of the TCR [Cohn, M., 2005c. The Tritope Model for restrictive recognition of antigen by T-cells. I. What assumptions about structure are needed to explain function? Mol. Immunol. 42, 1419-1443], a set of functional and evolutionary problems surrounding restrictive recognition of antigen are discussed. These include the origin of allele-specific recognition, the selection pressures for polygeneism and polymorphism, the TCR signaling interactions, the centrality of effector T-helper (eTh)-dependence for activation, the role of haplotype exclusion, nonclassical MHC-elements, alloreactivity versus xenoreactivity, etc. Further, a set of observations believed to support the Standard Model are reinterpreted." @default.
- W195374014 created "2016-06-24" @default.
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- W195374014 date "2008-02-01" @default.
- W195374014 modified "2023-09-27" @default.
- W195374014 title "The Tritope Model for restrictive recognition of antigen by T-cells" @default.
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- W195374014 doi "https://doi.org/10.1016/j.molimm.2006.02.033" @default.
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