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• W1954113487 abstract "Cyclic guanosine monophosphate (cGMP) is an essential second messenger metabolized by phosphodiesterases (PDEs).We looked for a possible correlation of PDE activities in human oral squamous cell carcinoma (OSCC) with and without lymph node metastases.The analysis of phosphodiesterase activity and the cGMP assay were done by reverse-phase HPLC on samples of fresh or frozen gingival tissues. Analysis of cGMP was confirmed with the enzyme-linked immunoabsorption assay.cGMP PDE activity was 34.92 +/- 7.17 SD, 12.89 +/- 4.43 SD, and 35.88 +/- 8.76 SD (nmols/mg of protein), respectively, in controls, samples without lymph node involvement (N-), and specimens with lymph node metastases (N+). cGMP values were 1.97 +/- 0.63 SD, 3.30 +/- 1.47 SD, and 3.49 +/- 1.47 SD (nmols/mg of protein). Our data support the hypothesis of a role for cGMP and PDE in the progression of OSCC." @default.
• W1954113487 created "2016-06-24" @default.
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• W1954113487 date "2003-03-24" @default.
• W1954113487 modified "2023-10-12" @default.
• W1954113487 title "Cyclic guanosine monophosphate phosphodiesterase activity in human gingival carcinoma" @default.
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• W1954113487 doi "https://doi.org/10.1034/j.1600-0714.2003.00083.x" @default.
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