FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1954161036> ?p ?o ?g. }

• W1954161036 endingPage "711" @default.
• W1954161036 startingPage "697" @default.
• W1954161036 abstract "Although the antiestrogen tamoxifen has been the mainstay of therapy for estrogen receptor (ER)-positive breast cancer, successful treatment of responsive tumors is often followed by the acquisition of tamoxifen resistance. Subsequently, only 30-40% of patients have a positive response to second hormonal therapies. This lack of response might be explained by mechanisms for tamoxifen resistance that sensitize ER pathways to small amounts of estrogenic activity present in tamoxifen or that bypass ER pathways completely. To elucidate one possible mechanism of tamoxifen resistance, we treated ovariectomized tumor-bearing mice injected with fibroblast growth factor (FGF)-transfected MCF-7 breast carcinoma cells with the steroidal antiestrogen ICI 182,780 or one of two aromatase inhibitors, 4-OHA or letrozole. These treatments did not slow estrogen-independent growth or prevent metastasis of tumors produced by FGF-transfected MCF-7 cells in ovariectomized nude mice. FGF-transfected cells had diminished responses to ICI 182,780 in vitro, suggesting that autocrine activity of the transfected FGF may be replacing estrogen as a mitogenic stimulus for tumor growth. ER levels in FGF transfectants were not down-regulated, and basal levels of transcripts for estrogen-induced genes or of ER-mediated transcription of estrogen response element (ERE) luciferase reporter constructs in the FGF expressing cells were not higher than parental cells, implying that altered hormonal responses are not due to down-regulation of ER or to FGF-mediated activation of ER. These studies indicate that estrogen independence may be achieved through FGF signaling pathways independent of ER pathways. If so, therapies directed at the operative mechanism might produce a therapeutic response or allow a response to a second course of antiestrogen treatment." @default.
• W1954161036 created "2016-06-24" @default.
• W1954161036 creator A5004347382 @default.
• W1954161036 creator A5005192959 @default.
• W1954161036 creator A5010930816 @default.
• W1954161036 creator A5015363484 @default.
• W1954161036 creator A5016782680 @default.
• W1954161036 creator A5035617308 @default.
• W1954161036 creator A5041008330 @default.
• W1954161036 creator A5041944037 @default.
• W1954161036 creator A5051707734 @default.
• W1954161036 creator A5076731884 @default.
• W1954161036 creator A5091200123 @default.
• W1954161036 date "1998-03-01" @default.
• W1954161036 modified "2023-10-06" @default.
• W1954161036 title "Tamoxifen-resistant fibroblast growth factor-transfected MCF-7 cells are cross-resistant in vivo to the antiestrogen ICI 182,780 and two aromatase inhibitors." @default.
• W1954161036 cites W1522280141 @default.
• W1954161036 cites W1971861967 @default.
• W1954161036 cites W2000523470 @default.
• W1954161036 cites W2009428030 @default.
• W1954161036 cites W2050102995 @default.
• W1954161036 cites W2137695810 @default.
• W1954161036 cites W2152088031 @default.
• W1954161036 cites W2157650470 @default.
• W1954161036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9533540" @default.
• W1954161036 hasPublicationYear "1998" @default.
• W1954161036 type Work @default.
• W1954161036 sameAs 1954161036 @default.
• W1954161036 citedByCount "19" @default.
• W1954161036 countsByYear W19541610362017 @default.
• W1954161036 countsByYear W19541610362019 @default.
• W1954161036 countsByYear W19541610362020 @default.
• W1954161036 countsByYear W19541610362023 @default.
• W1954161036 crossrefType "journal-article" @default.
• W1954161036 hasAuthorship W1954161036A5004347382 @default.
• W1954161036 hasAuthorship W1954161036A5005192959 @default.
• W1954161036 hasAuthorship W1954161036A5010930816 @default.
• W1954161036 hasAuthorship W1954161036A5015363484 @default.
• W1954161036 hasAuthorship W1954161036A5016782680 @default.
• W1954161036 hasAuthorship W1954161036A5035617308 @default.
• W1954161036 hasAuthorship W1954161036A5041008330 @default.
• W1954161036 hasAuthorship W1954161036A5041944037 @default.
• W1954161036 hasAuthorship W1954161036A5051707734 @default.
• W1954161036 hasAuthorship W1954161036A5076731884 @default.
• W1954161036 hasAuthorship W1954161036A5091200123 @default.
• W1954161036 hasConcept C109541995 @default.
• W1954161036 hasConcept C121608353 @default.
• W1954161036 hasConcept C126322002 @default.
• W1954161036 hasConcept C134018914 @default.
• W1954161036 hasConcept C170493617 @default.
• W1954161036 hasConcept C2776067312 @default.
• W1954161036 hasConcept C2776166826 @default.
• W1954161036 hasConcept C2777164284 @default.
• W1954161036 hasConcept C2777176818 @default.
• W1954161036 hasConcept C2994423619 @default.
• W1954161036 hasConcept C502942594 @default.
• W1954161036 hasConcept C530470458 @default.
• W1954161036 hasConcept C54009773 @default.
• W1954161036 hasConcept C54355233 @default.
• W1954161036 hasConcept C71924100 @default.
• W1954161036 hasConcept C74373430 @default.
• W1954161036 hasConcept C81885089 @default.
• W1954161036 hasConcept C84606932 @default.
• W1954161036 hasConcept C86803240 @default.
• W1954161036 hasConcept C96232424 @default.
• W1954161036 hasConceptScore W1954161036C109541995 @default.
• W1954161036 hasConceptScore W1954161036C121608353 @default.
• W1954161036 hasConceptScore W1954161036C126322002 @default.
• W1954161036 hasConceptScore W1954161036C134018914 @default.
• W1954161036 hasConceptScore W1954161036C170493617 @default.
• W1954161036 hasConceptScore W1954161036C2776067312 @default.
• W1954161036 hasConceptScore W1954161036C2776166826 @default.
• W1954161036 hasConceptScore W1954161036C2777164284 @default.
• W1954161036 hasConceptScore W1954161036C2777176818 @default.
• W1954161036 hasConceptScore W1954161036C2994423619 @default.
• W1954161036 hasConceptScore W1954161036C502942594 @default.
• W1954161036 hasConceptScore W1954161036C530470458 @default.
• W1954161036 hasConceptScore W1954161036C54009773 @default.
• W1954161036 hasConceptScore W1954161036C54355233 @default.
• W1954161036 hasConceptScore W1954161036C71924100 @default.
• W1954161036 hasConceptScore W1954161036C74373430 @default.
• W1954161036 hasConceptScore W1954161036C81885089 @default.
• W1954161036 hasConceptScore W1954161036C84606932 @default.
• W1954161036 hasConceptScore W1954161036C86803240 @default.
• W1954161036 hasConceptScore W1954161036C96232424 @default.
• W1954161036 hasIssue "3" @default.
• W1954161036 hasLocation W19541610361 @default.
• W1954161036 hasOpenAccess W1954161036 @default.
• W1954161036 hasPrimaryLocation W19541610361 @default.
• W1954161036 hasRelatedWork W1552511838 @default.
• W1954161036 hasRelatedWork W1911110831 @default.
• W1954161036 hasRelatedWork W1954161036 @default.
• W1954161036 hasRelatedWork W1992827635 @default.
• W1954161036 hasRelatedWork W2025170339 @default.
• W1954161036 hasRelatedWork W2034806427 @default.
• W1954161036 hasRelatedWork W2127890495 @default.
• W1954161036 hasRelatedWork W2167042538 @default.
• W1954161036 hasRelatedWork W4205461359 @default.

• next