FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1954165954> ?p ?o ?g. }

• W1954165954 abstract "Two challenging problems in the clinical study of cancer are the characterization of cancer subtypes and the classification of individual patients according to those subtypes. Statistical approaches addressing these problems are hampered by population heterogeneity and challenges inherent in data integration across high-dimensional, diverse covariates. We have developed a survival-supervised latent Dirichlet allocation (survLDA) modeling framework to address these concerns. LDA models have proven extremely effective at identifying themes common across large collections of text, but applications to genomics have been limited. Our framework extends LDA to the genome by considering each patient as a `document' with `text' constructed from clinical and high-dimensional genomic measurements. We then further extend the framework to allow for supervision by a time-to-event response. The model enables the efficient identification of collections of clinical and genomic features that co-occur within patient subgroups, and then characterizes each patient by those features. An application of survLDA to The Cancer Genome Atlas (TCGA) ovarian project identifies informative patient subgroups that are characterized by different propensities for exhibiting abnormal mRNA expression and methylations, corresponding to differential rates of survival from primary therapy." @default.
• W1954165954 created "2016-06-24" @default.
• W1954165954 creator A5075303013 @default.
• W1954165954 creator A5086207166 @default.
• W1954165954 date "2012-02-27" @default.
• W1954165954 modified "2023-09-27" @default.
• W1954165954 title "Survival-supervised latent Dirichlet allocation models for genomic analysis of time-to-event outcomes" @default.
• W1954165954 cites W1516111018 @default.
• W1954165954 cites W1580788756 @default.
• W1954165954 cites W1784537671 @default.
• W1954165954 cites W1880262756 @default.
• W1954165954 cites W1993286543 @default.
• W1954165954 cites W1993528080 @default.
• W1954165954 cites W2008929650 @default.
• W1954165954 cites W2011832962 @default.
• W1954165954 cites W2016707708 @default.
• W1954165954 cites W2023545216 @default.
• W1954165954 cites W2026011470 @default.
• W1954165954 cites W2048330531 @default.
• W1954165954 cites W2056287709 @default.
• W1954165954 cites W2059989630 @default.
• W1954165954 cites W2073116379 @default.
• W1954165954 cites W2097664282 @default.
• W1954165954 cites W2098062695 @default.
• W1954165954 cites W2115047198 @default.
• W1954165954 cites W2116209708 @default.
• W1954165954 cites W2119021772 @default.
• W1954165954 cites W2120340025 @default.
• W1954165954 cites W2123696077 @default.
• W1954165954 cites W2131593373 @default.
• W1954165954 cites W2138155367 @default.
• W1954165954 cites W2141025089 @default.
• W1954165954 cites W2146320559 @default.
• W1954165954 cites W2146341620 @default.
• W1954165954 cites W2150264652 @default.
• W1954165954 cites W2158266063 @default.
• W1954165954 cites W2171720857 @default.
• W1954165954 cites W2343272106 @default.
• W1954165954 cites W598898933 @default.
• W1954165954 hasPublicationYear "2012" @default.
• W1954165954 type Work @default.
• W1954165954 sameAs 1954165954 @default.
• W1954165954 citedByCount "3" @default.
• W1954165954 countsByYear W19541659542015 @default.
• W1954165954 countsByYear W19541659542017 @default.
• W1954165954 countsByYear W19541659542020 @default.
• W1954165954 crossrefType "posted-content" @default.
• W1954165954 hasAuthorship W1954165954A5075303013 @default.
• W1954165954 hasAuthorship W1954165954A5086207166 @default.
• W1954165954 hasConcept C104317684 @default.
• W1954165954 hasConcept C116834253 @default.
• W1954165954 hasConcept C119043178 @default.
• W1954165954 hasConcept C119857082 @default.
• W1954165954 hasConcept C121332964 @default.
• W1954165954 hasConcept C124101348 @default.
• W1954165954 hasConcept C141231307 @default.
• W1954165954 hasConcept C154945302 @default.
• W1954165954 hasConcept C171686336 @default.
• W1954165954 hasConcept C189206191 @default.
• W1954165954 hasConcept C2779662365 @default.
• W1954165954 hasConcept C2908647359 @default.
• W1954165954 hasConcept C41008148 @default.
• W1954165954 hasConcept C500882744 @default.
• W1954165954 hasConcept C54355233 @default.
• W1954165954 hasConcept C59822182 @default.
• W1954165954 hasConcept C62520636 @default.
• W1954165954 hasConcept C70721500 @default.
• W1954165954 hasConcept C71924100 @default.
• W1954165954 hasConcept C86803240 @default.
• W1954165954 hasConcept C99454951 @default.
• W1954165954 hasConceptScore W1954165954C104317684 @default.
• W1954165954 hasConceptScore W1954165954C116834253 @default.
• W1954165954 hasConceptScore W1954165954C119043178 @default.
• W1954165954 hasConceptScore W1954165954C119857082 @default.
• W1954165954 hasConceptScore W1954165954C121332964 @default.
• W1954165954 hasConceptScore W1954165954C124101348 @default.
• W1954165954 hasConceptScore W1954165954C141231307 @default.
• W1954165954 hasConceptScore W1954165954C154945302 @default.
• W1954165954 hasConceptScore W1954165954C171686336 @default.
• W1954165954 hasConceptScore W1954165954C189206191 @default.
• W1954165954 hasConceptScore W1954165954C2779662365 @default.
• W1954165954 hasConceptScore W1954165954C2908647359 @default.
• W1954165954 hasConceptScore W1954165954C41008148 @default.
• W1954165954 hasConceptScore W1954165954C500882744 @default.
• W1954165954 hasConceptScore W1954165954C54355233 @default.
• W1954165954 hasConceptScore W1954165954C59822182 @default.
• W1954165954 hasConceptScore W1954165954C62520636 @default.
• W1954165954 hasConceptScore W1954165954C70721500 @default.
• W1954165954 hasConceptScore W1954165954C71924100 @default.
• W1954165954 hasConceptScore W1954165954C86803240 @default.
• W1954165954 hasConceptScore W1954165954C99454951 @default.
• W1954165954 hasLocation W19541659541 @default.
• W1954165954 hasOpenAccess W1954165954 @default.
• W1954165954 hasPrimaryLocation W19541659541 @default.
• W1954165954 hasRelatedWork W1841364769 @default.
• W1954165954 hasRelatedWork W1880262756 @default.
• W1954165954 hasRelatedWork W2000161741 @default.
• W1954165954 hasRelatedWork W2403071867 @default.
• W1954165954 hasRelatedWork W2547245315 @default.
• W1954165954 hasRelatedWork W2739330662 @default.

• next