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• W1954222607 abstract "Abstract The Caenorhabditis elegans hermaphrodite is essentially a female that produces sperm. In C. elegans, tra-2 promotes female fates and must be repressed to achieve hermaphrodite spermatogenesis. In an effort to learn how mating systems evolve, we have cloned tra-2 from C. remanei, the closest gonochoristic relative of C. elegans. We found its structure to be similar to that of Ce-tra-2 but its sequence to be divergent. RNA interference demonstrates that Cr-tra-2 promotes female fates. Two sites of tra-2 regulation are required for the onset of hermaphrodite spermatogenesis in C. elegans. One, the MX region of TRA-2, is as well conserved in C. remanei as it is in C. briggsae (another male/hermaphrodite species), suggesting that this control is not unique to hermaphrodites. Another, the DRE/TGE element of the tra-2 3′ UTR, was not detected by sequence analysis. However, gel-shift assays demonstrate that a factor in C. remanei can bind specifically to the Cr-tra-2 3′ UTR, suggesting that this translational control is also conserved. We propose that both controls are general and do not constitute a novel “switch” that enables sexual mosaicism in hermaphrodites. However, subtle quantitative or qualitative differences in their employment may underlie differences in mating system seen in Caenorhabditis." @default.
• W1954222607 created "2016-06-24" @default.
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• W1954222607 date "2000-05-01" @default.
• W1954222607 modified "2023-10-18" @default.
• W1954222607 title "Regulatory Elements Required for Development of <i>Caenorhabditis elegans</i> Hermaphrodites Are Conserved in the <i>tra-2</i> Homologue of <i>C. remanei</i>, a Male/Female Sister Species" @default.
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• W1954222607 doi "https://doi.org/10.1093/genetics/155.1.105" @default.
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