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- W1954285908 abstract "Structured Abstract Authors – Warner DR, Greene RM, Pisano MM Objectives – To determine the in vivo interaction between Smad 3 and Dishevelled‐1. Design – Cell culture transfection followed by immunoprecipitation with specific antibodies. Setting and Sample Population – The Department of Molecular, Cellular, and Craniofacial Biology, Birth Defects Center, University of Louisville. Experimental Variable – Overexpression of myc‐Smad 3. Outcome Measure – Western blotting of anti‐Dishevelled immunoprecipitates for Smad 3. Results – Smad 3 and Dishevelled isoforms‐1, ‐2, and ‐3 all bind Smad 3 in glutathione‐S‐transferase (GST) pull‐down assays and Smad 3 binds to Dishevelled‐1 in vivo . Stimulation of the transforming growth factor beta (TGF β ) pathway leads to increased binding of Smad 3 and Dishevelled‐1 in vivo. Conclusion – Smad 3 binds all three known isoforms of Dishevelled and binds Dishevelled 1 in vivo . TGF β signaling modulates the interaction between Smad 3 and Dishevelled‐1." @default.
- W1954285908 created "2016-06-24" @default.
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- W1954285908 date "2005-05-01" @default.
- W1954285908 modified "2023-10-18" @default.
- W1954285908 title "Interaction between Smad 3 and Dishevelled in murine embryonic craniofacial mesenchymal cells" @default.
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- W1954285908 doi "https://doi.org/10.1111/j.1601-6343.2005.00319.x" @default.
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