FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1954302797> ?p ?o ?g. }

• W1954302797 endingPage "334" @default.
• W1954302797 startingPage "322" @default.
• W1954302797 abstract "Radioimmunoscintigraphy (RIS) is coming into its own as an imaging modality in clinical oncology. Early experience with indium-III-labeled intact murine monoclonal antibodies (MoAbs) in colorectal cancer suggested that RIS images hepatic metastases poorly. Moreover, an antimurine immune response was frequently provoked, precluding multiple follow-up RIS studies in individual patients due to reticu-loendothelial sequestration of the radioimmunoconjugate before tumor targeting could occur. Recent trials of technetium-99m- labeled antibody fragments and human MoAbs have demonstrated significant improvement in imaging efficacy, and repeated or serial imaging is possible because of the absence of associated immunoge-nicity. RIS is demonstrably more sensitive than conventional diagnostic modalities (CDM) such as computed tomography (CT)for detection of extrahepatic abdominal and pelvic colorectal carcinoma and is complementary to CDM in imaging liver metastases. In a surgical decision-making analysis comparing CT, RIS (IMMU-4 99mTc-Fab′; CEA-Scan®), and CT plus RIS in patients with recurrent or metastatic colorectal cancer, CT plus RIS improved correct prediction of resectability by 40% and correct prediction of unresectability by 100% compared with CT alone. At the present time, RIS used in combination with CDM contributes an incremental improvement in diagnostic accuracy in colorectal cancer patients with known or suspected recurrent disease. Basic and clinical research currently in progress promises to yield agents and methods that provide rapid high-resolution imaging, high tumor-to-background ratios in all organs at risk for tumor recurrence or metastasis, negligible immuno genicity and toxicity, and a signficant further improvement in the accuracy of clinical decision making in oncology patients." @default.
• W1954302797 created "2016-06-24" @default.
• W1954302797 creator A5008907100 @default.
• W1954302797 creator A5009064456 @default.
• W1954302797 creator A5012090924 @default.
• W1954302797 creator A5020675836 @default.
• W1954302797 creator A5027342903 @default.
• W1954302797 creator A5030557327 @default.
• W1954302797 creator A5064099470 @default.
• W1954302797 creator A5074348602 @default.
• W1954302797 creator A5078635119 @default.
• W1954302797 date "1999-01-01" @default.
• W1954302797 modified "2023-09-23" @default.
• W1954302797 title "A Thousand Points of Light or Just Dim Bulbs? Radiolabeled Antibodies and Colorectal Cancer Imaging" @default.
• W1954302797 cites W1891541666 @default.
• W1954302797 cites W1917079187 @default.
• W1954302797 cites W1968097451 @default.
• W1954302797 cites W1980489359 @default.
• W1954302797 cites W1982904756 @default.
• W1954302797 cites W1982987387 @default.
• W1954302797 cites W1989164132 @default.
• W1954302797 cites W1990732655 @default.
• W1954302797 cites W1998739227 @default.
• W1954302797 cites W2027201749 @default.
• W1954302797 cites W2027688190 @default.
• W1954302797 cites W2032707072 @default.
• W1954302797 cites W2037301270 @default.
• W1954302797 cites W2053953667 @default.
• W1954302797 cites W2055760743 @default.
• W1954302797 cites W2057164396 @default.
• W1954302797 cites W2064879288 @default.
• W1954302797 cites W2069414080 @default.
• W1954302797 cites W2069634707 @default.
• W1954302797 cites W2073916488 @default.
• W1954302797 cites W2089646233 @default.
• W1954302797 cites W2091609494 @default.
• W1954302797 cites W2091975109 @default.
• W1954302797 cites W2123542431 @default.
• W1954302797 cites W2155874405 @default.
• W1954302797 cites W2157736308 @default.
• W1954302797 cites W2167629244 @default.
• W1954302797 cites W2259978442 @default.
• W1954302797 cites W2317792746 @default.
• W1954302797 cites W2417282827 @default.
• W1954302797 doi "https://doi.org/10.3109/07357909909032874" @default.
• W1954302797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10370360" @default.
• W1954302797 hasPublicationYear "1999" @default.
• W1954302797 type Work @default.
• W1954302797 sameAs 1954302797 @default.
• W1954302797 citedByCount "24" @default.
• W1954302797 countsByYear W19543027972012 @default.
• W1954302797 countsByYear W19543027972017 @default.
• W1954302797 crossrefType "journal-article" @default.
• W1954302797 hasAuthorship W1954302797A5008907100 @default.
• W1954302797 hasAuthorship W1954302797A5009064456 @default.
• W1954302797 hasAuthorship W1954302797A5012090924 @default.
• W1954302797 hasAuthorship W1954302797A5020675836 @default.
• W1954302797 hasAuthorship W1954302797A5027342903 @default.
• W1954302797 hasAuthorship W1954302797A5030557327 @default.
• W1954302797 hasAuthorship W1954302797A5064099470 @default.
• W1954302797 hasAuthorship W1954302797A5074348602 @default.
• W1954302797 hasAuthorship W1954302797A5078635119 @default.
• W1954302797 hasConcept C121608353 @default.
• W1954302797 hasConcept C126322002 @default.
• W1954302797 hasConcept C126838900 @default.
• W1954302797 hasConcept C143998085 @default.
• W1954302797 hasConcept C2779013556 @default.
• W1954302797 hasConcept C2989005 @default.
• W1954302797 hasConcept C526805850 @default.
• W1954302797 hasConcept C535046627 @default.
• W1954302797 hasConcept C71924100 @default.
• W1954302797 hasConceptScore W1954302797C121608353 @default.
• W1954302797 hasConceptScore W1954302797C126322002 @default.
• W1954302797 hasConceptScore W1954302797C126838900 @default.
• W1954302797 hasConceptScore W1954302797C143998085 @default.
• W1954302797 hasConceptScore W1954302797C2779013556 @default.
• W1954302797 hasConceptScore W1954302797C2989005 @default.
• W1954302797 hasConceptScore W1954302797C526805850 @default.
• W1954302797 hasConceptScore W1954302797C535046627 @default.
• W1954302797 hasConceptScore W1954302797C71924100 @default.
• W1954302797 hasIssue "5" @default.
• W1954302797 hasLocation W19543027971 @default.
• W1954302797 hasLocation W19543027972 @default.
• W1954302797 hasOpenAccess W1954302797 @default.
• W1954302797 hasPrimaryLocation W19543027971 @default.
• W1954302797 hasRelatedWork W1970423756 @default.
• W1954302797 hasRelatedWork W2001756060 @default.
• W1954302797 hasRelatedWork W2049214470 @default.
• W1954302797 hasRelatedWork W2392730113 @default.
• W1954302797 hasRelatedWork W2732735609 @default.
• W1954302797 hasRelatedWork W2924913209 @default.
• W1954302797 hasRelatedWork W3004259476 @default.
• W1954302797 hasRelatedWork W3032265334 @default.
• W1954302797 hasRelatedWork W3032784534 @default.
• W1954302797 hasRelatedWork W3144757235 @default.
• W1954302797 hasVolume "17" @default.
• W1954302797 isParatext "false" @default.
• W1954302797 isRetracted "false" @default.

• next