Matches in SemOpenAlex for { <https://semopenalex.org/work/W1954879923> ?p ?o ?g. }
- W1954879923 abstract "Polyneuropathy associated with IgM monoclonal gammopathy is a predominantly sensory, slowly progressive neuropathy for which treatment options are limited. In about 10% of patients antibodies against gangliosides or ganglioside complexes can be found. These antibodies do not always arise from a monoclonal B cell population. Different anti-ganglioside antibody specificities are associated with different clinical phenotypes. IL-6 and IL-10 serum concentrations differ between patients with neuropathy and controls and between those with or without anti-MAG antibodies. For both patients with anti-MAG or anti-ganglioside antibodies Fcγ-receptor polymorphisms may predict the response to treatment with rituximab, a monoclonal therapeutic antibody against CD20. Careful selection of patients for treatment with rituximab is necessary as it may lead to paradoxical deteriotation of the neuropathy during treatment." @default.
- W1954879923 created "2016-06-24" @default.
- W1954879923 creator A5038871284 @default.
- W1954879923 date "2015-05-28" @default.
- W1954879923 modified "2023-09-26" @default.
- W1954879923 title "The role of auto-antibodies and paraproteinemia in polyneuropathy" @default.
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