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- W1954920279 abstract "Aim: Chronic obstructive pulmonary disease (COPD) patients are treated with several drugs for their primary disease and comorbidity, which carries the risk of clinically relevant drug-drug interactions (DDIs). We aimed to evaluate DDI in hospitalized COPD patients. Methods: This retrospective study included COPD patients hospitalized from January 2011 to July 2011 in a tertiary care clinic. Pharmacological therapy at admission and discharge was evaluated for DDI with electronic Lexi-Comp database: C- monitor therapy; D- consider therapy modification; X- avoid combination. Results: We included 196 patients (68% male, age 71 ±9 years). The average number of prescribed drugs was significantly lower at hospital admission than at discharge (6 ±3 vs. 7 ±2, p 2 -agonists (10% of cases) and the most prevalent type D interaction between β-blocker and α-blocker (9%). There were 15 type X interactions recorded at discharge, among which the most common was between non selective β-blocker and β2-adrenoreceptor agonist (8 cases) Conclusion: DDI are common in hospitalized patients with COPD but few carry clinically relevant risk. Most type X interactions were between non-selective β-blocker and β2-adrenoreceptor agonist which likely was indicated and should be safe in COPD patients." @default.
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- W1954920279 date "2012-09-01" @default.
- W1954920279 modified "2023-09-24" @default.
- W1954920279 title "Drug-drug interactions in hospitalized patients with chronic obstructive pulmonary disease" @default.
- W1954920279 hasPublicationYear "2012" @default.
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