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• W1955128431 endingPage "1259" @default.
• W1955128431 startingPage "1252" @default.
• W1955128431 abstract "We performed bolus inhalations of 1-μm particles in four subjects on the ground (1 G) and during parabolic flights both in microgravity (μG) and in ∼1.6 G. Boluses of ∼70 ml were inhaled at different points in an inspiration from residual volume to 1 liter above functional residual capacity. The volume of air inhaled after the bolus [the penetration volume (V p )] ranged from 200 to 1,500 ml. Aerosol concentration and flow rate were continuously measured at the mouth. The deposition, dispersion, and position of the bolus in the expired gas were calculated from these data. For V p ≥400 ml, both deposition and dispersion increased with V p and were strongly gravity dependent, with the greatest deposition and dispersion occurring for the largest G level. At V p = 800 ml, deposition and dispersion increased from 33.9% and 319 ml in μG to 56.9% and 573 ml at ∼1.6 G, respectively ( P < 0.05). At each G level, the bolus was expired at a smaller volume than V p , and this volume became smaller with increasing V p . Although dispersion was lower in μG than in 1 G and ∼1.6 G, it still increased steadily with increasing V p , showing that nongravitational ventilatory inhomogeneity is partly responsible for dispersion in the human lung." @default.
• W1955128431 created "2016-06-24" @default.
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• W1955128431 date "1998-10-01" @default.
• W1955128431 modified "2023-10-17" @default.
• W1955128431 title "Deposition and dispersion of 1-μm aerosol boluses in the human lung: effect of micro- and hypergravity" @default.
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• W1955128431 doi "https://doi.org/10.1152/jappl.1998.85.4.1252" @default.
• W1955128431 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9760313" @default.
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