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• W1955143133 abstract "Parboiled germinated brown rice (PGBR) of Khao Dawk Mali 105 variety was produced by steaming germinated paddy rice, which is well-known for its nutrients and bioactive compounds. In this study we determined the in vivo antioxidant and hepatoprotective effects of PGBR in carbon tetrachloride (CCl4)-induced oxidative stress in rats. Male Sprague-Dawley rats, (weight 200–250 g) were randomly divided into (1) control, (2) CCl4, (3) white rice (WR)+CCl4, (4) brown rice (BR)+CCl4, and (5) PGBR+CCl4 groups. PGBR, BR, and WR diets were produced by replacing corn starch in the AIN76A diet with cooked PGBR, BR, and WR powders, respectively. All rats except the control group were gavaged with 50% CCl4 in olive oil (v/v, 1 mL/kg) twice a week for 8 weeks. CCl4-treated rats exhibited significant liver injury, lipid peroxidation, protein oxidation, and DNA damage, as well as obvious changes to liver histopathology compared to control. In addition, CCl4 treatment decreased the activities of CYP2E1 and antioxidant enzymes: glutathione S-transferase, glutathione peroxidase, superoxide dismutase and catalase, and glutathione (GSH) content. However, the PGBR+CCl4 group exhibited less liver injury, lipid peroxidation, protein oxidation, and DNA damage, as well as better antioxidant enzyme activities and GSH content. Furthermore, PGBR inhibited degradation of CYP2E1 in CCl4-induced decrease of CYP2E1 activity. These data suggest that PGBR may prevent CCl4-induced liver oxidative stress and injury through enhancement of the antioxidant capacities, which may be due to complex actions of various bioactive compounds, including phenolic acids, γ-oryzanol, tocotrienol, and GABA." @default.
• W1955143133 created "2016-06-24" @default.
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• W1955143133 date "2016-01-01" @default.
• W1955143133 modified "2023-10-18" @default.
• W1955143133 title "Parboiled Germinated Brown Rice Protects Against CCl₄-Induced Oxidative Stress and Liver Injury in Rats" @default.
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• W1955143133 doi "https://doi.org/10.1089/jmf.2015.3460" @default.
• W1955143133 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26075965" @default.
• W1955143133 hasPublicationYear "2016" @default.
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