FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1955247866> ?p ?o ?g. }

• W1955247866 endingPage "1624" @default.
• W1955247866 startingPage "1618" @default.
• W1955247866 abstract "Shiga toxin B chain, the binding subunit of Shiga toxin, was recently purified; and the amino acid sequence of this 7,716-dalton polypeptide was determined (N.G. Seidah, A. Donohue-Rolfe, C. Lazure, F. Auclair, G. T. Keusch, and M. Chretien, J. Biol. Chem. 261:13928-13931, 1986). In the present study, synthetic peptides corresponding to three overlapping sequences from the N-terminal region of this subunit were prepared. The peptides synthesized consisted of residues 5 to 18, 13 to 26, and 7 to 26. This region coincides with the major peak of hydrophilicity and surface area residues predicted from a computer analysis. For the purpose of immunization, the peptides either were conjugated with a protein or synthetic carrier or were polymerized with glutaraldehyde. Antisera against these peptide derivatives raised in rabbits reacted not only with the respective homologous peptide but also to a comparable extent with the intact Shiga toxin. The anti-peptide antisera effectively neutralized the various biological activities of the Shiga toxin, namely, cytotoxicity to HeLa cells, enterotoxic activity (the fluid secretion into ligated ileal loops in rats), and neurotoxicity in mice. Furthermore, active immunization with the peptide conjugates was found to protect mice against the lethal effect of Shiga toxin." @default.
• W1955247866 created "2016-06-24" @default.
• W1955247866 creator A5002039237 @default.
• W1955247866 creator A5023658482 @default.
• W1955247866 creator A5056949628 @default.
• W1955247866 creator A5091113056 @default.
• W1955247866 date "1988-06-01" @default.
• W1955247866 modified "2023-09-26" @default.
• W1955247866 title "Synthetic peptides of Shiga toxin B subunit induce antibodies which neutralize its biological activity" @default.
• W1955247866 cites W1526140678 @default.
• W1955247866 cites W1569081627 @default.
• W1955247866 cites W1708081159 @default.
• W1955247866 cites W1781482825 @default.
• W1955247866 cites W1881868864 @default.
• W1955247866 cites W1966548233 @default.
• W1955247866 cites W1978548965 @default.
• W1955247866 cites W1991638630 @default.
• W1955247866 cites W2000682235 @default.
• W1955247866 cites W2005362253 @default.
• W1955247866 cites W2013167867 @default.
• W1955247866 cites W2015888849 @default.
• W1955247866 cites W202617938 @default.
• W1955247866 cites W2043023293 @default.
• W1955247866 cites W2053418558 @default.
• W1955247866 cites W2059032160 @default.
• W1955247866 cites W2060565971 @default.
• W1955247866 cites W2061885915 @default.
• W1955247866 cites W2067570700 @default.
• W1955247866 cites W2068600514 @default.
• W1955247866 cites W2071240836 @default.
• W1955247866 cites W2074484003 @default.
• W1955247866 cites W2087202599 @default.
• W1955247866 cites W2091919937 @default.
• W1955247866 cites W2101108802 @default.
• W1955247866 cites W2152244146 @default.
• W1955247866 cites W2204341768 @default.
• W1955247866 cites W2263531331 @default.
• W1955247866 cites W2320556745 @default.
• W1955247866 cites W2322125076 @default.
• W1955247866 doi "https://doi.org/10.1128/iai.56.6.1618-1624.1988" @default.
• W1955247866 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/259446" @default.
• W1955247866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3286503" @default.
• W1955247866 hasPublicationYear "1988" @default.
• W1955247866 type Work @default.
• W1955247866 sameAs 1955247866 @default.
• W1955247866 citedByCount "56" @default.
• W1955247866 countsByYear W19552478662013 @default.
• W1955247866 countsByYear W19552478662014 @default.
• W1955247866 countsByYear W19552478662015 @default.
• W1955247866 countsByYear W19552478662020 @default.
• W1955247866 countsByYear W19552478662021 @default.
• W1955247866 crossrefType "journal-article" @default.
• W1955247866 hasAuthorship W1955247866A5002039237 @default.
• W1955247866 hasAuthorship W1955247866A5023658482 @default.
• W1955247866 hasAuthorship W1955247866A5056949628 @default.
• W1955247866 hasAuthorship W1955247866A5091113056 @default.
• W1955247866 hasBestOaLocation W19552478661 @default.
• W1955247866 hasConcept C104292427 @default.
• W1955247866 hasConcept C104317684 @default.
• W1955247866 hasConcept C109316439 @default.
• W1955247866 hasConcept C153911025 @default.
• W1955247866 hasConcept C159654299 @default.
• W1955247866 hasConcept C167625842 @default.
• W1955247866 hasConcept C202751555 @default.
• W1955247866 hasConcept C203014093 @default.
• W1955247866 hasConcept C2777367657 @default.
• W1955247866 hasConcept C2779281246 @default.
• W1955247866 hasConcept C49039625 @default.
• W1955247866 hasConcept C55493867 @default.
• W1955247866 hasConcept C86803240 @default.
• W1955247866 hasConcept C91523082 @default.
• W1955247866 hasConceptScore W1955247866C104292427 @default.
• W1955247866 hasConceptScore W1955247866C104317684 @default.
• W1955247866 hasConceptScore W1955247866C109316439 @default.
• W1955247866 hasConceptScore W1955247866C153911025 @default.
• W1955247866 hasConceptScore W1955247866C159654299 @default.
• W1955247866 hasConceptScore W1955247866C167625842 @default.
• W1955247866 hasConceptScore W1955247866C202751555 @default.
• W1955247866 hasConceptScore W1955247866C203014093 @default.
• W1955247866 hasConceptScore W1955247866C2777367657 @default.
• W1955247866 hasConceptScore W1955247866C2779281246 @default.
• W1955247866 hasConceptScore W1955247866C49039625 @default.
• W1955247866 hasConceptScore W1955247866C55493867 @default.
• W1955247866 hasConceptScore W1955247866C86803240 @default.
• W1955247866 hasConceptScore W1955247866C91523082 @default.
• W1955247866 hasIssue "6" @default.
• W1955247866 hasLocation W19552478661 @default.
• W1955247866 hasLocation W19552478662 @default.
• W1955247866 hasOpenAccess W1955247866 @default.
• W1955247866 hasPrimaryLocation W19552478661 @default.
• W1955247866 hasRelatedWork W1620939222 @default.
• W1955247866 hasRelatedWork W1958187136 @default.
• W1955247866 hasRelatedWork W1973692620 @default.
• W1955247866 hasRelatedWork W1981994265 @default.
• W1955247866 hasRelatedWork W2013552773 @default.
• W1955247866 hasRelatedWork W2112373131 @default.
• W1955247866 hasRelatedWork W2359730144 @default.
• W1955247866 hasRelatedWork W2369348973 @default.

• next