Matches in SemOpenAlex for { <https://semopenalex.org/work/W1955417823> ?p ?o ?g. }
- W1955417823 abstract "Publisher Summary Epstein-Barr virus (EBV) is responsible for the pathogenesis of tumors arising in both lymphoid and epithelial tissues. The virus adopts different forms of latent infection in different tumor types reflecting the complex interplay between EBV and the host cell environment. EBNA1, an essential protein for the maintenance of EBV infection has evolved. It evades immunosurveillance by developing a strategy that prevents the protein being processed through the MHC class I pathway. Studies of the function of individual EBV latent genes have highlighted the ability of these proteins to target specific cell signaling pathways. An understanding of the functions of EBV latent proteins is relevant to the role of the virus in transformation and in addition helps to elucidate the mechanisms regulating cell growth, survival, and differentiation. The chapter provides novel approaches to therapy. Adoptive transfer of EBV-specific cytotoxic T lymphocytes (CTLs) has proved useful in the treatment of immunoblastic B cell lymphomas. The possibility of more direct therapeutic intervention targeting the function of essential EBV latent genes, such as EBNA1 and LMP1, is also a possibility. Thus, drugs that prevent the ability of EBNA1 to bind to oriP or of the TRAFs to interact with LMP1 are developed. The gene therapy strategies that exploit the transcriptional regulation of the EBV genome or target the functional effects of EBV latent genes have been described." @default.
- W1955417823 created "2016-06-24" @default.
- W1955417823 creator A5057196333 @default.
- W1955417823 date "2001-01-01" @default.
- W1955417823 modified "2023-09-27" @default.
- W1955417823 title "Epstein-Barr virus and oncogenesis: From tumors to transforming genes" @default.
- W1955417823 cites W143287638 @default.
- W1955417823 cites W1489865648 @default.
- W1955417823 cites W1491749295 @default.
- W1955417823 cites W15076310 @default.
- W1955417823 cites W1510178802 @default.
- W1955417823 cites W1510771440 @default.
- W1955417823 cites W1528320858 @default.
- W1955417823 cites W1532391364 @default.
- W1955417823 cites W1541892819 @default.
- W1955417823 cites W1548083336 @default.
- W1955417823 cites W1550709242 @default.
- W1955417823 cites W1562827330 @default.
- W1955417823 cites W1581524975 @default.
- W1955417823 cites W1598586133 @default.
- W1955417823 cites W1601529283 @default.
- W1955417823 cites W1706373226 @default.
- W1955417823 cites W1729442292 @default.
- W1955417823 cites W1743459636 @default.
- W1955417823 cites W1774370734 @default.
- W1955417823 cites W1946498671 @default.
- W1955417823 cites W1963761369 @default.
- W1955417823 cites W1965467050 @default.
- W1955417823 cites W1967094994 @default.
- W1955417823 cites W1969165297 @default.
- W1955417823 cites W1970269101 @default.
- W1955417823 cites W1973061854 @default.
- W1955417823 cites W1975510548 @default.
- W1955417823 cites W1976337084 @default.
- W1955417823 cites W1976888905 @default.
- W1955417823 cites W1985082049 @default.
- W1955417823 cites W1985234536 @default.
- W1955417823 cites W1986364244 @default.
- W1955417823 cites W1986559713 @default.
- W1955417823 cites W1991226842 @default.
- W1955417823 cites W1993546845 @default.
- W1955417823 cites W1996168666 @default.
- W1955417823 cites W1997347525 @default.
- W1955417823 cites W2012161992 @default.
- W1955417823 cites W2013586951 @default.
- W1955417823 cites W2014140505 @default.
- W1955417823 cites W2016548488 @default.
- W1955417823 cites W2021464282 @default.
- W1955417823 cites W2022277753 @default.
- W1955417823 cites W2023269331 @default.
- W1955417823 cites W2023530705 @default.
- W1955417823 cites W2027998343 @default.
- W1955417823 cites W2031162215 @default.
- W1955417823 cites W2031636971 @default.
- W1955417823 cites W2033965249 @default.
- W1955417823 cites W2035638697 @default.
- W1955417823 cites W2035800680 @default.
- W1955417823 cites W2036187216 @default.
- W1955417823 cites W2038952378 @default.
- W1955417823 cites W2040549887 @default.
- W1955417823 cites W2041624767 @default.
- W1955417823 cites W2042690900 @default.
- W1955417823 cites W2042814875 @default.
- W1955417823 cites W2048737737 @default.
- W1955417823 cites W2048905748 @default.
- W1955417823 cites W2050064956 @default.
- W1955417823 cites W2050129013 @default.
- W1955417823 cites W2050787470 @default.
- W1955417823 cites W2053102794 @default.
- W1955417823 cites W2057728618 @default.
- W1955417823 cites W2057749060 @default.
- W1955417823 cites W2059833979 @default.
- W1955417823 cites W2060001883 @default.
- W1955417823 cites W2060083603 @default.
- W1955417823 cites W2061319065 @default.
- W1955417823 cites W2063175140 @default.
- W1955417823 cites W2065187149 @default.
- W1955417823 cites W2066784330 @default.
- W1955417823 cites W2067680656 @default.
- W1955417823 cites W2069292681 @default.
- W1955417823 cites W2069566008 @default.
- W1955417823 cites W2071497481 @default.
- W1955417823 cites W2076665646 @default.
- W1955417823 cites W2077910054 @default.
- W1955417823 cites W2082678443 @default.
- W1955417823 cites W2085220509 @default.
- W1955417823 cites W2088549259 @default.
- W1955417823 cites W2089651572 @default.
- W1955417823 cites W2092536138 @default.
- W1955417823 cites W2101856856 @default.
- W1955417823 cites W2104882344 @default.
- W1955417823 cites W2112016055 @default.
- W1955417823 cites W2112569925 @default.
- W1955417823 cites W2119661777 @default.
- W1955417823 cites W2124660059 @default.
- W1955417823 cites W2126784935 @default.
- W1955417823 cites W2127534803 @default.
- W1955417823 cites W2133074755 @default.
- W1955417823 cites W2134538928 @default.
- W1955417823 cites W2139159276 @default.