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- W1955694611 abstract "Traumatic brain injury (TBI) often results in persistent attention and memory deficits that are associated with hippocampal dysfunction. Although deep brain stimulation (DBS) is used to treat neurological disorders related to motor dysfunction, the effectiveness of stimulation to treat cognition remains largely unknown. In this study, adult male Harlan Sprague-Dawley rats underwent a lateral fluid percussion or sham injury followed by implantation of bipolar electrodes in the medial septal nucleus (MSN) and ipsilateral hippocampus. In the first week after injury, there was a significant decrease in hippocampal theta oscillations that correlated with decreased object exploration and impaired performance in the Barnes maze spatial learning task. Continuous 7.7 Hz theta stimulation of the medial septum significantly increased hippocampal theta oscillations, restored normal object exploration, and improved spatial learning in injured animals. There were no benefits with 100 Hz gamma stimulation, and stimulation of sham animals at either frequency did not enhance performance. We conclude, therefore, that there was a theta frequency-specific benefit of DBS that restored cognitive function in brain-injured rats. These data suggest that septal theta stimulation may be an effective and novel neuromodulatory therapy for treatment of persistent cognitive deficits following TBI." @default.
- W1955694611 created "2016-06-24" @default.
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- W1955694611 date "2015-11-15" @default.
- W1955694611 modified "2023-10-05" @default.
- W1955694611 title "Septohippocampal Neuromodulation Improves Cognition after Traumatic Brain Injury" @default.
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- W1955694611 cites W1978250666 @default.
- W1955694611 cites W1982567191 @default.
- W1955694611 cites W1997210687 @default.
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- W1955694611 cites W2006952639 @default.
- W1955694611 cites W2008357008 @default.
- W1955694611 cites W2008539925 @default.
- W1955694611 cites W2009532273 @default.
- W1955694611 cites W2016776195 @default.
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- W1955694611 cites W2024325218 @default.
- W1955694611 cites W2025180344 @default.
- W1955694611 cites W2025722246 @default.
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- W1955694611 cites W2031131009 @default.
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- W1955694611 cites W2058482789 @default.
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- W1955694611 doi "https://doi.org/10.1089/neu.2014.3744" @default.
- W1955694611 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4702430" @default.
- W1955694611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26096267" @default.
- W1955694611 hasPublicationYear "2015" @default.
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