FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1955860674> ?p ?o ?g. }

• W1955860674 endingPage "12447" @default.
• W1955860674 startingPage "12440" @default.
• W1955860674 abstract "Cancer of unknown primary (CUP) accounts for approximately 3% of all malignancies. Despite extensive laboratory and imaging efforts, the primary site usually cannot be unequivocally confirmed, and the treatment for the most part remains empirical. Recently, identification of common cancer pathway alterations in diverse cancer lineages has offered an opportunity to provide targeted therapies for patients with CUP, irrespective of the primary site.1806 cancers of unknown primary were identified among more than 63,000 cases profiled at Caris Life Sciences. Multiplatform profiling of the tumor samples included immunohistochemistry, gene sequencing and in situ hybridization methods in an effort to identify changes in biomarkers that are predictive of drug responses.Biomarkers associated with a potential drug benefit were identified in 96% of cases. Biomarkers identified included those associated with potential benefit in nearly all classes of approved cancer drugs (cytotoxic, hormonal, targeted biological drugs). Additionally, biomarkers associated with a potential lack of benefit were identified in numerous cases, which could further refine the management of patients with CUP.Comprehensive biomarker profiling of CUP may provide additional choices in treatment of patients with these difficult to treat malignancies." @default.
• W1955860674 created "2016-06-24" @default.
• W1955860674 creator A5037644603 @default.
• W1955860674 creator A5043031975 @default.
• W1955860674 creator A5046522995 @default.
• W1955860674 creator A5069485497 @default.
• W1955860674 creator A5074267076 @default.
• W1955860674 creator A5080900202 @default.
• W1955860674 creator A5089791667 @default.
• W1955860674 date "2014-10-31" @default.
• W1955860674 modified "2023-10-18" @default.
• W1955860674 title "Comprehensive tumor profiling identifies numerous biomarkers of drug response in cancers of unknown primary site: Analysis of 1806 cases" @default.
• W1955860674 cites W164704903 @default.
• W1955860674 cites W1803857749 @default.
• W1955860674 cites W1943869846 @default.
• W1955860674 cites W1963928345 @default.
• W1955860674 cites W1971938884 @default.
• W1955860674 cites W1981172391 @default.
• W1955860674 cites W1981272958 @default.
• W1955860674 cites W1995435221 @default.
• W1955860674 cites W1996689640 @default.
• W1955860674 cites W2007523256 @default.
• W1955860674 cites W2010624323 @default.
• W1955860674 cites W2014881369 @default.
• W1955860674 cites W2022495797 @default.
• W1955860674 cites W2025731839 @default.
• W1955860674 cites W2032648482 @default.
• W1955860674 cites W2038444072 @default.
• W1955860674 cites W2054261652 @default.
• W1955860674 cites W2063044598 @default.
• W1955860674 cites W2072010297 @default.
• W1955860674 cites W2097200850 @default.
• W1955860674 cites W2111435123 @default.
• W1955860674 cites W2124211545 @default.
• W1955860674 cites W2124662474 @default.
• W1955860674 cites W2135131549 @default.
• W1955860674 cites W2139327979 @default.
• W1955860674 cites W2141670106 @default.
• W1955860674 cites W2156251761 @default.
• W1955860674 cites W2158420602 @default.
• W1955860674 cites W2161179758 @default.
• W1955860674 cites W2161375781 @default.
• W1955860674 cites W2335128207 @default.
• W1955860674 cites W4239268588 @default.
• W1955860674 cites W4240897294 @default.
• W1955860674 cites W4245276995 @default.
• W1955860674 doi "https://doi.org/10.18632/oncotarget.2574" @default.
• W1955860674 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4322997" @default.
• W1955860674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25415047" @default.
• W1955860674 hasPublicationYear "2014" @default.
• W1955860674 type Work @default.
• W1955860674 sameAs 1955860674 @default.
• W1955860674 citedByCount "57" @default.
• W1955860674 countsByYear W19558606742015 @default.
• W1955860674 countsByYear W19558606742016 @default.
• W1955860674 countsByYear W19558606742017 @default.
• W1955860674 countsByYear W19558606742018 @default.
• W1955860674 countsByYear W19558606742019 @default.
• W1955860674 countsByYear W19558606742020 @default.
• W1955860674 countsByYear W19558606742021 @default.
• W1955860674 countsByYear W19558606742022 @default.
• W1955860674 countsByYear W19558606742023 @default.
• W1955860674 crossrefType "journal-article" @default.
• W1955860674 hasAuthorship W1955860674A5037644603 @default.
• W1955860674 hasAuthorship W1955860674A5043031975 @default.
• W1955860674 hasAuthorship W1955860674A5046522995 @default.
• W1955860674 hasAuthorship W1955860674A5069485497 @default.
• W1955860674 hasAuthorship W1955860674A5074267076 @default.
• W1955860674 hasAuthorship W1955860674A5080900202 @default.
• W1955860674 hasAuthorship W1955860674A5089791667 @default.
• W1955860674 hasBestOaLocation W19558606741 @default.
• W1955860674 hasConcept C104317684 @default.
• W1955860674 hasConcept C111919701 @default.
• W1955860674 hasConcept C121608353 @default.
• W1955860674 hasConcept C124535831 @default.
• W1955860674 hasConcept C126322002 @default.
• W1955860674 hasConcept C142724271 @default.
• W1955860674 hasConcept C143998085 @default.
• W1955860674 hasConcept C187191949 @default.
• W1955860674 hasConcept C2779013556 @default.
• W1955860674 hasConcept C2780035454 @default.
• W1955860674 hasConcept C2780283643 @default.
• W1955860674 hasConcept C2781197716 @default.
• W1955860674 hasConcept C2994119904 @default.
• W1955860674 hasConcept C3019646584 @default.
• W1955860674 hasConcept C41008148 @default.
• W1955860674 hasConcept C46111723 @default.
• W1955860674 hasConcept C55493867 @default.
• W1955860674 hasConcept C60644358 @default.
• W1955860674 hasConcept C70721500 @default.
• W1955860674 hasConcept C71924100 @default.
• W1955860674 hasConcept C86803240 @default.
• W1955860674 hasConcept C98274493 @default.
• W1955860674 hasConceptScore W1955860674C104317684 @default.
• W1955860674 hasConceptScore W1955860674C111919701 @default.
• W1955860674 hasConceptScore W1955860674C121608353 @default.
• W1955860674 hasConceptScore W1955860674C124535831 @default.
• W1955860674 hasConceptScore W1955860674C126322002 @default.

• next