Matches in SemOpenAlex for { <https://semopenalex.org/work/W1955965722> ?p ?o ?g. }
- W1955965722 endingPage "735" @default.
- W1955965722 startingPage "726" @default.
- W1955965722 abstract "1. Prospective and interventional studies demonstrate an inverse relationship between plasma high-density lipoprotein (HDL)-cholesterol and the incidence of coronary artery disease. Although the atheroprotective effects of HDL are usually attributed to the reverse cholesterol transport, in which HDL shuttles cholesterol from cells in the arterial wall to the liver, other mechanisms are also under investigation. 2. Platelets are involved in both the initiation and progression of atherosclerotic lesions. In addition, the formation of thrombi over ruptured atherosclerotic plaques results in the narrowing or complete occlusion of coronary arteries. Current experimental evidence suggests that HDL may exert antiplatelet effects and thereby counteract the development of atherothrombotic vascular disease. 3. In vitro studies show that HDL inhibits agonist-stimulated platelet aggregation, fibrinogen binding, granule secretion and liberation of thromboxane A(2). Inhibitory effects of HDL are mediated, in part, by scavenger receptor type B1 and/or the apolipoprotein E receptor apoER2/LRP8 and are linked to the induction of intracellular signalling cascades encompassing stimulation of protein kinase C, cytoplasmatic alkalization and generation of nitric oxide. 4. Populational studies demonstrate that there is an inverse association between plasma HDL levels and recurrent venous thromboembolism. In addition, HDL-cholesterol has been identified as an independent predictor of acute platelet thrombus formation. The administration of reconstituted HDL particles in humans attenuates ex vivo platelet activation. 5. The present review summarizes recent advances in understanding HDL-platelet interactions and discusses the potential use of HDL-like particles in the therapy of thrombosis." @default.
- W1955965722 created "2016-06-24" @default.
- W1955965722 creator A5024282703 @default.
- W1955965722 creator A5035295431 @default.
- W1955965722 creator A5052535635 @default.
- W1955965722 date "2010-03-12" @default.
- W1955965722 modified "2023-10-08" @default.
- W1955965722 title "High-density lipoproteins, platelets and the pathogenesis of atherosclerosis" @default.
- W1955965722 cites W1499386671 @default.
- W1955965722 cites W1510774040 @default.
- W1955965722 cites W1561516029 @default.
- W1955965722 cites W1588516858 @default.
- W1955965722 cites W1595467693 @default.
- W1955965722 cites W17992636 @default.
- W1955965722 cites W1811100095 @default.
- W1955965722 cites W1919571783 @default.
- W1955965722 cites W1947925671 @default.
- W1955965722 cites W1963915605 @default.
- W1955965722 cites W1965592696 @default.
- W1955965722 cites W1965983458 @default.
- W1955965722 cites W1969200048 @default.
- W1955965722 cites W1969327353 @default.
- W1955965722 cites W1969876465 @default.
- W1955965722 cites W1970959706 @default.
- W1955965722 cites W1973178110 @default.
- W1955965722 cites W1977644543 @default.
- W1955965722 cites W1981793725 @default.
- W1955965722 cites W1984054820 @default.
- W1955965722 cites W1985810150 @default.
- W1955965722 cites W1990422782 @default.
- W1955965722 cites W1991295549 @default.
- W1955965722 cites W1993261838 @default.
- W1955965722 cites W1994768909 @default.
- W1955965722 cites W1996256445 @default.
- W1955965722 cites W1996317289 @default.
- W1955965722 cites W2000230992 @default.
- W1955965722 cites W2002340463 @default.
- W1955965722 cites W2006666326 @default.
- W1955965722 cites W2010296946 @default.
- W1955965722 cites W2010895019 @default.
- W1955965722 cites W2011768933 @default.
- W1955965722 cites W2011785451 @default.
- W1955965722 cites W2015139547 @default.
- W1955965722 cites W2015973819 @default.
- W1955965722 cites W2016116867 @default.
- W1955965722 cites W2016531738 @default.
- W1955965722 cites W2017873104 @default.
- W1955965722 cites W2027545927 @default.
- W1955965722 cites W2029684068 @default.
- W1955965722 cites W2032811951 @default.
- W1955965722 cites W2034890527 @default.
- W1955965722 cites W2038312431 @default.
- W1955965722 cites W2040176292 @default.
- W1955965722 cites W2048043120 @default.
- W1955965722 cites W2048760408 @default.
- W1955965722 cites W2050923219 @default.
- W1955965722 cites W2051134788 @default.
- W1955965722 cites W2054065847 @default.
- W1955965722 cites W2058196012 @default.
- W1955965722 cites W2059335341 @default.
- W1955965722 cites W2061705098 @default.
- W1955965722 cites W2064685216 @default.
- W1955965722 cites W2066736055 @default.
- W1955965722 cites W2072190804 @default.
- W1955965722 cites W2076552482 @default.
- W1955965722 cites W2077420019 @default.
- W1955965722 cites W2078617119 @default.
- W1955965722 cites W2078628617 @default.
- W1955965722 cites W2079633354 @default.
- W1955965722 cites W2079926187 @default.
- W1955965722 cites W2081213583 @default.
- W1955965722 cites W2085108261 @default.
- W1955965722 cites W2086200383 @default.
- W1955965722 cites W2087782461 @default.
- W1955965722 cites W2087825777 @default.
- W1955965722 cites W2090744742 @default.
- W1955965722 cites W2093104471 @default.
- W1955965722 cites W2098101490 @default.
- W1955965722 cites W2101186431 @default.
- W1955965722 cites W2101310235 @default.
- W1955965722 cites W2104226967 @default.
- W1955965722 cites W2108381329 @default.
- W1955965722 cites W2113250420 @default.
- W1955965722 cites W2113456155 @default.
- W1955965722 cites W2114810042 @default.
- W1955965722 cites W2114991100 @default.
- W1955965722 cites W2115220026 @default.
- W1955965722 cites W2116456927 @default.
- W1955965722 cites W2117383170 @default.
- W1955965722 cites W2117430800 @default.
- W1955965722 cites W2120808705 @default.
- W1955965722 cites W2122568158 @default.
- W1955965722 cites W2122574767 @default.
- W1955965722 cites W2124421822 @default.
- W1955965722 cites W2124989653 @default.
- W1955965722 cites W2127510556 @default.
- W1955965722 cites W2128008950 @default.
- W1955965722 cites W2134551277 @default.