Matches in SemOpenAlex for { <https://semopenalex.org/work/W1956223863> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W1956223863 endingPage "8" @default.
- W1956223863 startingPage "991" @default.
- W1956223863 abstract "Culture of the human melanoma cell line MeWo in the presence of 1 mM theophylline was associated with an increase in susceptibility to natural killer (NK)-mediated cytolysis. The phenomenon was detected as early as 72 hours after initiation of theophylline treatment, reaching maximum values at 3-4 weeks and remaining stable for longer than 3 months of testing, provided the cells were maintained in the presence of theophylline. The alteration in target sensitivity was selective for NK-mediated cytolysis, since other mechanisms of cell-mediated cytolysis, including antibody-dependent cell-mediated cytotoxicity and monocyte-mediated and lectin-induced cytolysis, were comparable between untreated and treated cells. The enhanced susceptibility of theophylline-treated cultures to NK lysis, as compared to NK lysis susceptibility of untreated MeWo cells, was not significantly changed by pretreatment of effector lymphocytes with interferon. Evidence for differentiation in theophylline-treated cultures was obtained. In addition, however, cytofluorometric and karyologic analysis revealed the existence of two subpopulations of differing ploidy in the MeWo line. The hypodiploid, NK-sensitive subpopulation, bearing homogeneously staining regions on two chromosomes, could be selected by growth in theophylline. Therefore, selection of subpopulations in heterogeneous tumor cell lines by chemical inducers suggests an alternative and novel mechanism for enhancement of NK sensitivity." @default.
- W1956223863 created "2016-06-24" @default.
- W1956223863 creator A5007228053 @default.
- W1956223863 creator A5007554042 @default.
- W1956223863 creator A5008238353 @default.
- W1956223863 creator A5009048718 @default.
- W1956223863 creator A5014724390 @default.
- W1956223863 creator A5016729281 @default.
- W1956223863 creator A5021367203 @default.
- W1956223863 creator A5031463576 @default.
- W1956223863 creator A5035062788 @default.
- W1956223863 creator A5059794647 @default.
- W1956223863 creator A5074187114 @default.
- W1956223863 date "1984-05-01" @default.
- W1956223863 modified "2023-09-27" @default.
- W1956223863 title "Enhanced natural killer sensitivity with concomitant clonal selection for cells bearing homogeneously staining regions in the human melanoma cell line MeWo upon induction of differentiation with theophylline." @default.
- W1956223863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6201643" @default.
- W1956223863 hasPublicationYear "1984" @default.
- W1956223863 type Work @default.
- W1956223863 sameAs 1956223863 @default.
- W1956223863 citedByCount "3" @default.
- W1956223863 crossrefType "journal-article" @default.
- W1956223863 hasAuthorship W1956223863A5007228053 @default.
- W1956223863 hasAuthorship W1956223863A5007554042 @default.
- W1956223863 hasAuthorship W1956223863A5008238353 @default.
- W1956223863 hasAuthorship W1956223863A5009048718 @default.
- W1956223863 hasAuthorship W1956223863A5014724390 @default.
- W1956223863 hasAuthorship W1956223863A5016729281 @default.
- W1956223863 hasAuthorship W1956223863A5021367203 @default.
- W1956223863 hasAuthorship W1956223863A5031463576 @default.
- W1956223863 hasAuthorship W1956223863A5035062788 @default.
- W1956223863 hasAuthorship W1956223863A5059794647 @default.
- W1956223863 hasAuthorship W1956223863A5074187114 @default.
- W1956223863 hasConcept C109316439 @default.
- W1956223863 hasConcept C134018914 @default.
- W1956223863 hasConcept C153911025 @default.
- W1956223863 hasConcept C202751555 @default.
- W1956223863 hasConcept C203014093 @default.
- W1956223863 hasConcept C2778095195 @default.
- W1956223863 hasConcept C2778102761 @default.
- W1956223863 hasConcept C502942594 @default.
- W1956223863 hasConcept C54355233 @default.
- W1956223863 hasConcept C55493867 @default.
- W1956223863 hasConcept C73588182 @default.
- W1956223863 hasConcept C81885089 @default.
- W1956223863 hasConcept C86803240 @default.
- W1956223863 hasConceptScore W1956223863C109316439 @default.
- W1956223863 hasConceptScore W1956223863C134018914 @default.
- W1956223863 hasConceptScore W1956223863C153911025 @default.
- W1956223863 hasConceptScore W1956223863C202751555 @default.
- W1956223863 hasConceptScore W1956223863C203014093 @default.
- W1956223863 hasConceptScore W1956223863C2778095195 @default.
- W1956223863 hasConceptScore W1956223863C2778102761 @default.
- W1956223863 hasConceptScore W1956223863C502942594 @default.
- W1956223863 hasConceptScore W1956223863C54355233 @default.
- W1956223863 hasConceptScore W1956223863C55493867 @default.
- W1956223863 hasConceptScore W1956223863C73588182 @default.
- W1956223863 hasConceptScore W1956223863C81885089 @default.
- W1956223863 hasConceptScore W1956223863C86803240 @default.
- W1956223863 hasIssue "5" @default.
- W1956223863 hasLocation W19562238631 @default.
- W1956223863 hasOpenAccess W1956223863 @default.
- W1956223863 hasPrimaryLocation W19562238631 @default.
- W1956223863 hasRelatedWork W168872323 @default.
- W1956223863 hasRelatedWork W1956223863 @default.
- W1956223863 hasRelatedWork W1979560728 @default.
- W1956223863 hasRelatedWork W2003671591 @default.
- W1956223863 hasRelatedWork W2028350003 @default.
- W1956223863 hasRelatedWork W2029644809 @default.
- W1956223863 hasRelatedWork W2059238306 @default.
- W1956223863 hasRelatedWork W2075343875 @default.
- W1956223863 hasRelatedWork W2357021796 @default.
- W1956223863 hasRelatedWork W2405233669 @default.
- W1956223863 hasVolume "72" @default.
- W1956223863 isParatext "false" @default.
- W1956223863 isRetracted "false" @default.
- W1956223863 magId "1956223863" @default.
- W1956223863 workType "article" @default.