FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1956261057> ?p ?o ?g. }

• W1956261057 abstract "Background: Attention deficit/hyperactivity disorder (AD/HD) and autism spectrum disorders (ASDs) are early-onset, but often life-time impairing, neurodevelopmental disorders. They are highly overlapping and seem to carry considerable risks of negative outcomes, psychiatrically and psychosocially. Childhood hyperactivity is a known risk factor for early-onset conduct disorder (CD), but details concerning the associations between neurodevelopmental problems, aggression, and antisocial personality disorder (ASPD) in adult age are still uncertain. The current diagnostic subdivision of the ASDs is based on children, while the adult characteristics, including patterns of comorbidity and psychosocial adversities, have been less studied, especially in subjects without concomitant intellectual disability. Objectives: The overall aim of this thesis was to describe the adult outcome of AD/HD and ASDs. Specific aims were to: (1) review prospective, longitudinal studies of the adult outcome of childhood hyperactivity, equivalent to AD/HD, with special regard to ASPD, (2) investigate the relationships between AD/HD, ASDs, and different types of aggressive behaviours, (3) describe the clinical presentation, including personality development and psychosocial outcome, in normal-intelligence adult subjects with ASDs. Method: The first paper is a systematic meta-analysis of published studies. The subsequent studies are descriptive analyses of common clinical assessment protocols from consecutive groups of adults either referred for clinical evaluations of childhood-onset neuropsychiatric disorders, for forensic psychiatric investigations, or recruited to a population-based, longitudinal study of teenage-onset anorexia nervosa (AN). Results: Childhood hyperactivity increases the risk for CD, which is found in at least one-third of all hyperactive children, forming the starting point for the development of aggressive antisociality in adulthood in about half of cases with the combination of hyperactivity and CD in childhood. Support for the hypothesis that childhood hyperactivity, in the absence of early CD, carries a risk for adult ASPD, is still lacking (Paper I). Both conditions are, however, predictors of aggression in adults, together with substance-related disorders and poor development of the character trait Cooperativeness. ASD traits or symptoms did not generally predict aggression but may be associated with unique violent offences (Paper II). Among subjects with normal-intelligence ASDs, life-time psychiatric comorbidity was very high, and measures of outcome indicated low psychosocial functioning. AD/HD was common in all ASD subject categories studied with the notable exception of subjects with AN, none of whom had AD/HD. ASPD and substance-related disorders were more common in patients with an atypical ASD as compared to Asperger´s disorder or autistic disorder. Among all adults diagnosed with an ASD, less than half led an independent life and comparatively few had ever had a long-term relationship. Female subjects more often reported having been bullied at school than male subjects (Paper III and IV). Discussion and conclusions: Childhood-onset neuropsychiatric conditions such as AD/HD and ASDs are relevant for adult psychiatric phenotypes but insufficiently studied. Current classifications suffer from the hiatus between child- and adolescent psychiatry and adult psychiatry and future diagnostic concepts ought to be longitudinal with a life-time perspective on cognitive and emotional development and a patient-centred focus rather than fragmented into complex patterns of “comorbidities”." @default.
• W1956261057 created "2016-06-24" @default.
• W1956261057 creator A5005103487 @default.
• W1956261057 date "2009-01-01" @default.
• W1956261057 modified "2023-09-24" @default.
• W1956261057 title "AD/HD and autism spectrum disorders in adults" @default.
• W1956261057 cites W133846886 @default.
• W1956261057 cites W149359538 @default.
• W1956261057 cites W1497698943 @default.
• W1956261057 cites W1509186521 @default.
• W1956261057 cites W1515141642 @default.
• W1956261057 cites W1538480409 @default.
• W1956261057 cites W1560349878 @default.
• W1956261057 cites W1561235154 @default.
• W1956261057 cites W1569728608 @default.
• W1956261057 cites W1574339853 @default.
• W1956261057 cites W1574778776 @default.
• W1956261057 cites W1576458038 @default.
• W1956261057 cites W1579719239 @default.
• W1956261057 cites W1588816394 @default.
• W1956261057 cites W1589516474 @default.
• W1956261057 cites W1592989986 @default.
• W1956261057 cites W1747874104 @default.
• W1956261057 cites W17720952 @default.
• W1956261057 cites W1773116645 @default.
• W1956261057 cites W1784545427 @default.
• W1956261057 cites W1827729071 @default.
• W1956261057 cites W1832711705 @default.
• W1956261057 cites W1914703486 @default.
• W1956261057 cites W1919874270 @default.
• W1956261057 cites W1923665259 @default.
• W1956261057 cites W1927933718 @default.
• W1956261057 cites W1931231146 @default.
• W1956261057 cites W1956328280 @default.
• W1956261057 cites W1964028885 @default.
• W1956261057 cites W1964136259 @default.
• W1956261057 cites W1964523530 @default.
• W1956261057 cites W1965260390 @default.
• W1956261057 cites W1967249950 @default.
• W1956261057 cites W1967948106 @default.
• W1956261057 cites W1969337703 @default.
• W1956261057 cites W1970293309 @default.
• W1956261057 cites W1970329190 @default.
• W1956261057 cites W1970834718 @default.
• W1956261057 cites W1971098431 @default.
• W1956261057 cites W1971569077 @default.
• W1956261057 cites W1972615526 @default.
• W1956261057 cites W1973868390 @default.
• W1956261057 cites W1974462465 @default.
• W1956261057 cites W1974513532 @default.
• W1956261057 cites W1974681461 @default.
• W1956261057 cites W1976539542 @default.
• W1956261057 cites W1977346630 @default.
• W1956261057 cites W1977444258 @default.
• W1956261057 cites W1978104670 @default.
• W1956261057 cites W1979172694 @default.
• W1956261057 cites W1979346919 @default.
• W1956261057 cites W1979793123 @default.
• W1956261057 cites W1983111444 @default.
• W1956261057 cites W1983365600 @default.
• W1956261057 cites W1983560405 @default.
• W1956261057 cites W1983826994 @default.
• W1956261057 cites W1983935388 @default.
• W1956261057 cites W1985179680 @default.
• W1956261057 cites W1989745025 @default.
• W1956261057 cites W1989844817 @default.
• W1956261057 cites W1991004352 @default.
• W1956261057 cites W1991445431 @default.
• W1956261057 cites W1992630740 @default.
• W1956261057 cites W1992942249 @default.
• W1956261057 cites W1995362640 @default.
• W1956261057 cites W1996352181 @default.
• W1956261057 cites W1997773831 @default.
• W1956261057 cites W1998090778 @default.
• W1956261057 cites W1998740954 @default.
• W1956261057 cites W1999266140 @default.
• W1956261057 cites W2001110716 @default.
• W1956261057 cites W2002176092 @default.
• W1956261057 cites W2002403033 @default.
• W1956261057 cites W2003968885 @default.
• W1956261057 cites W2006822204 @default.
• W1956261057 cites W2008940806 @default.
• W1956261057 cites W2009975323 @default.
• W1956261057 cites W2010265379 @default.
• W1956261057 cites W2010604180 @default.
• W1956261057 cites W2010677928 @default.
• W1956261057 cites W2010931158 @default.
• W1956261057 cites W2012077163 @default.
• W1956261057 cites W2012344497 @default.
• W1956261057 cites W2012453547 @default.
• W1956261057 cites W2013536305 @default.
• W1956261057 cites W2014599024 @default.
• W1956261057 cites W2015104943 @default.
• W1956261057 cites W2015669753 @default.
• W1956261057 cites W2016511885 @default.
• W1956261057 cites W2016945111 @default.
• W1956261057 cites W2019465651 @default.
• W1956261057 cites W2021417407 @default.
• W1956261057 cites W2021849865 @default.
• W1956261057 cites W2022274171 @default.

• next