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- W1956277275 abstract "Abstract Due to the long half‐life of commonly used therapeutic proteins (TPs) such as mAbs and the difficulty in many cases to recruit patients for trial enrollment, the conduct of well‐designed clinical interaction studies is generally costly and difficult. Therefore, there is astrong desire to develop in vitro approaches allowing predictions of whether significantinteractions between TPs and small molecules are likely. This chapter providesan overview of the current literature on the effects of proinflammatory cytokines on absorption, distribution, metabolism, and excretion (ADME) genes in vitro and provides a perspective on the current challenges and future opportunities to establish improved in vitro systems." @default.
- W1956277275 created "2016-06-24" @default.
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- W1956277275 date "2013-06-19" @default.
- W1956277275 modified "2023-10-17" @default.
- W1956277275 title "Utility of<i>In Vitro</i>Methods in Drug-Drug Interaction Assessment and Prediction for Therapeutic Biologics" @default.
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- W1956277275 doi "https://doi.org/10.1002/9780470571224.pse476" @default.
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