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- W1956285448 abstract "By virtue of its control over major histocompatibility complex class II (MHC-II) gene expression, CIITA represents a key molecule in the regulation of adaptive immune responses. It was first identified as a factor that is defective in MHC-II deficiency, a hereditary disease characterized by the absence of MHC-II expression. CIITA is a highly regulated transactivator that governs all spatial, temporal, and quantitative aspects of MHC-II expression. It has been proposed to act as a non-DNA-binding transcriptional coactivator, but evidence that it actually functions at the level of MHC-II promoters was lacking. By means of chromatin immunoprecipitation assays, we show here for the first time that CIITA is physically associated with MHC-II, as well as HLA–DM , Ii , MHC-I, and β 2 m promoters in vivo. To dissect the mechanism by which CIITA is recruited to the promoter, we have developed a DNA-dependent coimmunoprecipitation assay and a pull-down assay using immobilized promoter templates. We demonstrate that CIITA recruitment depends on multiple, synergistic protein–protein interactions with DNA-bound factors constituting the MHC-II enhanceosome. CIITA therefore represents a paradigm for a novel type of regulatory and gene-specific transcriptional cofactor." @default.
- W1956285448 created "2016-06-24" @default.
- W1956285448 creator A5008689678 @default.
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- W1956285448 date "2000-05-01" @default.
- W1956285448 modified "2023-10-17" @default.
- W1956285448 title "CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex" @default.
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- W1956285448 doi "https://doi.org/10.1101/gad.14.9.1156" @default.
- W1956285448 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/316580" @default.
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- W1956285448 hasPublicationYear "2000" @default.
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