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• W1956410312 abstract "The pathogenic Cryptococcus species consisting of Cryptococcus neoformans and Cryptococcus gattii are the principal cause of cryptococcosis which is a highly infectious global fungal disease of humans as well as animals. Cryptococcosis once considered as a sleeping giant has become an awakening giant after the discovery of human immune deficiency virus. It constitutes a major public health problem both in developed as well as developing countries. Globally, one million cases of cryptococcal meningitis occur every year in HIV/AIDS patients resulting in nearly 625,000 deaths. Cryptococcus gattii has emerged as an important mycotic agent which causes a significant burden on human and animal health. Global warming may be one of the important factors associated with the emergence of Cryptococcus gattii in some regions of the world. The pathogen, Cryptococcus gattii, has a propensity to infect mainly the immunocompetent subjects. It is found in the soil, air, water and trees. The source of infection is exogenous and the respiratory tract is recognized as the principal portal of entry of Cryptococcus gattii. The humans and animals may acquire the infection from the saprobic reservoirs. Both the fungi can be easily isolated from clinical and environmental samples on Pal sunflower seed medium. However, differentiation of Cryptococcus gattii from Cryptococcus neoformans requires L-canavaline-glycine- bromothymol blue agar. Molecular techniques are useful to identify the several genotypes of Cryptococcus gattii. A number of drugs such as amphotericin B, flucytosine, fluconazole and itraconazole are tried for the treatment of cryptococcal infection. Multidisciplinary approach is imperative to understand the dynamics of Cryptococcus gattii infection. Further studies on the ecologic niches, risk factors and therapeutic agents will be fruitful. Since animal infections due to Cryptococcus gattii are often a sentinel for human infection, the veterinarians are advised to immediately report the incident of cryptococcal disease." @default.
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• W1956410312 date "2014-01-01" @default.
• W1956410312 modified "2023-09-23" @default.
• W1956410312 title "Cryptococcus gattii: An emerging global mycotic pathogen of humans and animals" @default.
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