FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1956410366> ?p ?o ?g. }

• W1956410366 endingPage "42" @default.
• W1956410366 startingPage "34" @default.
• W1956410366 abstract "Abstract Hepatic and renal impairment studies were conducted with ruxolitinib, a JAK1&2 inhibitor that is cleared predominantly by metabolism. Both studies were open label, single‐dose studies. Ruxolitinib area under the curve (AUC) was increased by 87%, 28%, and 65%, respectively, in subjects with mild, moderate, and severe hepatic impairment compared to healthy subjects with no correlation between exposure of ruxolitinib and the degree of hepatic impairment. The pharmacodynamics (PD) data were consistent with ruxolitinib pharmacokinetics (PK). The renal impairment study showed a surprising finding. While there was no change in ruxolitinib PK with varying degrees of renal impairment, the PD showed increasing pharmacological activity with increased severity of renal impairment. Analysis of the metabolite exposures revealed that active metabolites contributed to the observed incremental increase in PD activity. The recovery of ruxolitinib in dialysate was negligible. The starting dose of ruxolitinib in subjects with any hepatic impairment or moderate or severe renal impairment should be decreased to 10 mg twice daily (BID) if their platelet counts are between 100 × 10 9 /L and 150 × 10 9 /L. Subjects on dialysis should initiate dosing with a single dose of 15 or 20 mg, based on platelet counts, with dosing only on the days of dialysis." @default.
• W1956410366 created "2016-06-24" @default.
• W1956410366 creator A5011862588 @default.
• W1956410366 creator A5012830519 @default.
• W1956410366 creator A5018193992 @default.
• W1956410366 creator A5026919490 @default.
• W1956410366 creator A5032817666 @default.
• W1956410366 creator A5041230347 @default.
• W1956410366 creator A5054787908 @default.
• W1956410366 creator A5066047781 @default.
• W1956410366 creator A5066209236 @default.
• W1956410366 creator A5086946489 @default.
• W1956410366 date "2013-10-19" @default.
• W1956410366 modified "2023-10-09" @default.
• W1956410366 title "Pharmacokinetics and pharmacodynamics of orally administered ruxolitinib (INCB018424 phosphate) in renal and hepatic impairment patients" @default.
• W1956410366 cites W1596479595 @default.
• W1956410366 cites W2021198354 @default.
• W1956410366 cites W2026977556 @default.
• W1956410366 cites W2036955341 @default.
• W1956410366 cites W2050094658 @default.
• W1956410366 cites W2055864845 @default.
• W1956410366 cites W2059200513 @default.
• W1956410366 cites W2060123467 @default.
• W1956410366 cites W2077149526 @default.
• W1956410366 cites W2079645940 @default.
• W1956410366 cites W2081847353 @default.
• W1956410366 cites W2083875968 @default.
• W1956410366 cites W2085754548 @default.
• W1956410366 cites W2089526947 @default.
• W1956410366 cites W2115351357 @default.
• W1956410366 cites W2121743767 @default.
• W1956410366 cites W2123274543 @default.
• W1956410366 cites W2123633897 @default.
• W1956410366 cites W2127632164 @default.
• W1956410366 cites W2142501647 @default.
• W1956410366 cites W2588792742 @default.
• W1956410366 doi "https://doi.org/10.1002/cpdd.77" @default.
• W1956410366 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27128228" @default.
• W1956410366 hasPublicationYear "2013" @default.
• W1956410366 type Work @default.
• W1956410366 sameAs 1956410366 @default.
• W1956410366 citedByCount "27" @default.
• W1956410366 countsByYear W19564103662015 @default.
• W1956410366 countsByYear W19564103662016 @default.
• W1956410366 countsByYear W19564103662017 @default.
• W1956410366 countsByYear W19564103662018 @default.
• W1956410366 countsByYear W19564103662019 @default.
• W1956410366 countsByYear W19564103662020 @default.
• W1956410366 countsByYear W19564103662021 @default.
• W1956410366 countsByYear W19564103662022 @default.
• W1956410366 countsByYear W19564103662023 @default.
• W1956410366 crossrefType "journal-article" @default.
• W1956410366 hasAuthorship W1956410366A5011862588 @default.
• W1956410366 hasAuthorship W1956410366A5012830519 @default.
• W1956410366 hasAuthorship W1956410366A5018193992 @default.
• W1956410366 hasAuthorship W1956410366A5026919490 @default.
• W1956410366 hasAuthorship W1956410366A5032817666 @default.
• W1956410366 hasAuthorship W1956410366A5041230347 @default.
• W1956410366 hasAuthorship W1956410366A5054787908 @default.
• W1956410366 hasAuthorship W1956410366A5066047781 @default.
• W1956410366 hasAuthorship W1956410366A5066209236 @default.
• W1956410366 hasAuthorship W1956410366A5086946489 @default.
• W1956410366 hasConcept C111113717 @default.
• W1956410366 hasConcept C112705442 @default.
• W1956410366 hasConcept C126322002 @default.
• W1956410366 hasConcept C149151106 @default.
• W1956410366 hasConcept C2776112149 @default.
• W1956410366 hasConcept C2777288759 @default.
• W1956410366 hasConcept C2779978075 @default.
• W1956410366 hasConcept C2780007613 @default.
• W1956410366 hasConcept C2780076729 @default.
• W1956410366 hasConcept C71924100 @default.
• W1956410366 hasConcept C90924648 @default.
• W1956410366 hasConcept C98274493 @default.
• W1956410366 hasConceptScore W1956410366C111113717 @default.
• W1956410366 hasConceptScore W1956410366C112705442 @default.
• W1956410366 hasConceptScore W1956410366C126322002 @default.
• W1956410366 hasConceptScore W1956410366C149151106 @default.
• W1956410366 hasConceptScore W1956410366C2776112149 @default.
• W1956410366 hasConceptScore W1956410366C2777288759 @default.
• W1956410366 hasConceptScore W1956410366C2779978075 @default.
• W1956410366 hasConceptScore W1956410366C2780007613 @default.
• W1956410366 hasConceptScore W1956410366C2780076729 @default.
• W1956410366 hasConceptScore W1956410366C71924100 @default.
• W1956410366 hasConceptScore W1956410366C90924648 @default.
• W1956410366 hasConceptScore W1956410366C98274493 @default.
• W1956410366 hasIssue "1" @default.
• W1956410366 hasLocation W19564103661 @default.
• W1956410366 hasLocation W19564103662 @default.
• W1956410366 hasOpenAccess W1956410366 @default.
• W1956410366 hasPrimaryLocation W19564103661 @default.
• W1956410366 hasRelatedWork W1582185909 @default.
• W1956410366 hasRelatedWork W2092462163 @default.
• W1956410366 hasRelatedWork W2184879058 @default.
• W1956410366 hasRelatedWork W2532202680 @default.
• W1956410366 hasRelatedWork W2752073795 @default.
• W1956410366 hasRelatedWork W2887049930 @default.
• W1956410366 hasRelatedWork W3016444371 @default.

• next