FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W19564557> ?p ?o ?g. }

• W19564557 endingPage "43" @default.
• W19564557 startingPage "337" @default.
• W19564557 abstract "Contact allergens sensitize the immune system by the binding to and subsequent activation of Langerhans cells (LCs), the antigen-presenting cells of the skin. At present, new chemicals are usually tested for their contact allergenicity in animal models. To develop an animal-replacing predictive in vivo assay for the identification of potential contact allergens, we compared the effects of epicutaneous application of six known contact allergens, five known irritants and two dermatologically inactive chemicals on LCs in skin biopsy cultures from seven healthy donors. Immunohistochemical analysis of cryostat sections of all the biopsies treated with contact allergens showed 1) a large reduction in the number of LCs in epidermis, as evaluated by a decrease in human leukocyte antigens (HLA)-DR-expressing cells, and CD1a-expressing cells and 2) accumulation of the remaining LCs at the epidermal-dermal junction. In contrast, the irritants, inactive chemicals, and solvents did not induce these changes. Morphometrical analysis indicated that the contact allergen-induced reduction in the number of HLA-DR+ and CD1a+ LCs per millimeter of epidermis was significant and was dependent on the concentration of the contact allergens. Flow cytometric analysis of isolated epidermal cells confirmed the immunohistochemical findings. In combination, these results suggest that the culture of ex vivo human skin explants provides a promising model to predict potential allergenicity of newly produced chemical compounds and can therefore replace current animal models." @default.
• W19564557 created "2016-06-24" @default.
• W19564557 creator A5003612103 @default.
• W19564557 creator A5018399610 @default.
• W19564557 creator A5035589556 @default.
• W19564557 creator A5049114747 @default.
• W19564557 creator A5068576526 @default.
• W19564557 creator A5072803795 @default.
• W19564557 creator A5087156062 @default.
• W19564557 date "1996-07-01" @default.
• W19564557 modified "2023-09-26" @default.
• W19564557 title "Novel predictive assay for contact allergens using human skin explant cultures." @default.
• W19564557 cites W1505516118 @default.
• W19564557 cites W1510470032 @default.
• W19564557 cites W1537862765 @default.
• W19564557 cites W1983601075 @default.
• W19564557 cites W1985662871 @default.
• W19564557 cites W1989770629 @default.
• W19564557 cites W1990889624 @default.
• W19564557 cites W1999005496 @default.
• W19564557 cites W2000062025 @default.
• W19564557 cites W2009690601 @default.
• W19564557 cites W2015429979 @default.
• W19564557 cites W2018811190 @default.
• W19564557 cites W2022638862 @default.
• W19564557 cites W2038564281 @default.
• W19564557 cites W2045561638 @default.
• W19564557 cites W2053283022 @default.
• W19564557 cites W2061766685 @default.
• W19564557 cites W2062098652 @default.
• W19564557 cites W2062508965 @default.
• W19564557 cites W2075541573 @default.
• W19564557 cites W2090321465 @default.
• W19564557 cites W2094997465 @default.
• W19564557 cites W2101186488 @default.
• W19564557 cites W2102081649 @default.
• W19564557 cites W2129322904 @default.
• W19564557 cites W2136754445 @default.
• W19564557 cites W2148726934 @default.
• W19564557 cites W2163520050 @default.
• W19564557 cites W2200533445 @default.
• W19564557 cites W225745863 @default.
• W19564557 cites W2315421440 @default.
• W19564557 cites W2403009991 @default.
• W19564557 cites W2411141845 @default.
• W19564557 cites W2425161088 @default.
• W19564557 cites W2427095890 @default.
• W19564557 cites W2429421599 @default.
• W19564557 cites W57044752 @default.
• W19564557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1865230" @default.
• W19564557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8686758" @default.
• W19564557 hasPublicationYear "1996" @default.
• W19564557 type Work @default.
• W19564557 sameAs 19564557 @default.
• W19564557 citedByCount "10" @default.
• W19564557 crossrefType "journal-article" @default.
• W19564557 hasAuthorship W19564557A5003612103 @default.
• W19564557 hasAuthorship W19564557A5018399610 @default.
• W19564557 hasAuthorship W19564557A5035589556 @default.
• W19564557 hasAuthorship W19564557A5049114747 @default.
• W19564557 hasAuthorship W19564557A5068576526 @default.
• W19564557 hasAuthorship W19564557A5072803795 @default.
• W19564557 hasAuthorship W19564557A5087156062 @default.
• W19564557 hasConcept C105702510 @default.
• W19564557 hasConcept C142724271 @default.
• W19564557 hasConcept C147483822 @default.
• W19564557 hasConcept C150903083 @default.
• W19564557 hasConcept C157890192 @default.
• W19564557 hasConcept C202751555 @default.
• W19564557 hasConcept C203014093 @default.
• W19564557 hasConcept C204232928 @default.
• W19564557 hasConcept C207001950 @default.
• W19564557 hasConcept C207480886 @default.
• W19564557 hasConcept C26291073 @default.
• W19564557 hasConcept C2776056826 @default.
• W19564557 hasConcept C2776458125 @default.
• W19564557 hasConcept C2777459323 @default.
• W19564557 hasConcept C2778091633 @default.
• W19564557 hasConcept C2778379841 @default.
• W19564557 hasConcept C2780510475 @default.
• W19564557 hasConcept C54355233 @default.
• W19564557 hasConcept C55493867 @default.
• W19564557 hasConcept C71924100 @default.
• W19564557 hasConcept C86803240 @default.
• W19564557 hasConcept C8891405 @default.
• W19564557 hasConceptScore W19564557C105702510 @default.
• W19564557 hasConceptScore W19564557C142724271 @default.
• W19564557 hasConceptScore W19564557C147483822 @default.
• W19564557 hasConceptScore W19564557C150903083 @default.
• W19564557 hasConceptScore W19564557C157890192 @default.
• W19564557 hasConceptScore W19564557C202751555 @default.
• W19564557 hasConceptScore W19564557C203014093 @default.
• W19564557 hasConceptScore W19564557C204232928 @default.
• W19564557 hasConceptScore W19564557C207001950 @default.
• W19564557 hasConceptScore W19564557C207480886 @default.
• W19564557 hasConceptScore W19564557C26291073 @default.
• W19564557 hasConceptScore W19564557C2776056826 @default.
• W19564557 hasConceptScore W19564557C2776458125 @default.

• next