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- W1956486503 startingPage "863" @default.
- W1956486503 abstract "The facilitated diffusion of glucose, galactose, fructose, urate, myoinositol, and dehydroascorbicacid in mammals is catalyzed by a family of 14 monosaccharide transport proteins called GLUTs. These transporters may be divided into three classes according to sequence similarity and function/substrate specificity. GLUT1 appears to be highly expressed in glycolytically active cells and has been coopted in vitamin C auxotrophs to maintain the redox state of the blood through transport of dehydroascorbate. Several GLUTs are definitive glucose/galactose transporters, GLUT2 and GLUT5 are physiologically important fructose transporters, GLUT9 appears to be a urate transporter while GLUT13 is a proton/myoinositol cotransporter. The physiologic substrates of some GLUTs remain to be established. The GLUTs are expressed in a tissue specific manner where affinity, specificity, and capacity for substrate transport are paramount for tissue function. Although great strides have been made in characterizing GLUT-catalyzed monosaccharide transport and mapping GLUT membrane topography and determinants of substrate specificity, a unifying model for GLUT structure and function remains elusive. The GLUTs play a major role in carbohydrate homeostasis and the redistribution of sugar-derived carbons among the various organ systems. This is accomplished through a multiplicity of GLUT-dependent glucose sensing and effector mechanisms that regulate monosaccharide ingestion, absorption,distribution, cellular transport and metabolism, and recovery/retention. Glucose transport and metabolism have coevolved in mammals to support cerebral glucose utilization." @default.
- W1956486503 created "2016-06-24" @default.
- W1956486503 creator A5018113693 @default.
- W1956486503 creator A5048162050 @default.
- W1956486503 date "2012-04-01" @default.
- W1956486503 modified "2023-10-02" @default.
- W1956486503 title "Role of Monosaccharide Transport Proteins in Carbohydrate Assimilation, Distribution, Metabolism, and Homeostasis" @default.
- W1956486503 cites W104554780 @default.
- W1956486503 cites W10571485 @default.
- W1956486503 cites W1177369452 @default.
- W1956486503 cites W146700098 @default.
- W1956486503 cites W1484205564 @default.
- W1956486503 cites W1487230427 @default.
- W1956486503 cites W1492408334 @default.
- W1956486503 cites W1493067895 @default.
- W1956486503 cites W1493089230 @default.
- W1956486503 cites W1496347561 @default.
- W1956486503 cites W1499640159 @default.
- W1956486503 cites W1501069255 @default.
- W1956486503 cites W1501403934 @default.
- W1956486503 cites W1502119684 @default.
- W1956486503 cites W1503802325 @default.
- W1956486503 cites W1506787748 @default.
- W1956486503 cites W1518504934 @default.
- W1956486503 cites W1519680742 @default.
- W1956486503 cites W1524305582 @default.
- W1956486503 cites W1525152404 @default.
- W1956486503 cites W1528581371 @default.
- W1956486503 cites W152880127 @default.
- W1956486503 cites W1529178114 @default.
- W1956486503 cites W1537087455 @default.
- W1956486503 cites W1542691236 @default.
- W1956486503 cites W1544588529 @default.
- W1956486503 cites W1545785706 @default.
- W1956486503 cites W1547869774 @default.
- W1956486503 cites W1559922603 @default.
- W1956486503 cites W1573834280 @default.
- W1956486503 cites W1574424832 @default.
- W1956486503 cites W1574505285 @default.
- W1956486503 cites W1578136772 @default.
- W1956486503 cites W1578684030 @default.
- W1956486503 cites W1579245019 @default.
- W1956486503 cites W1580646470 @default.
- W1956486503 cites W1590290940 @default.
- W1956486503 cites W1590981745 @default.
- W1956486503 cites W1599321131 @default.
- W1956486503 cites W1599563761 @default.
- W1956486503 cites W1603195684 @default.
- W1956486503 cites W1605224830 @default.
- W1956486503 cites W1607226074 @default.
- W1956486503 cites W1625152287 @default.
- W1956486503 cites W1655827168 @default.
- W1956486503 cites W1664312070 @default.
- W1956486503 cites W1668671560 @default.
- W1956486503 cites W1675624120 @default.
- W1956486503 cites W1693014831 @default.
- W1956486503 cites W1713784035 @default.
- W1956486503 cites W1734956365 @default.
- W1956486503 cites W1759385300 @default.
- W1956486503 cites W1759490885 @default.
- W1956486503 cites W1773423156 @default.
- W1956486503 cites W1775274730 @default.
- W1956486503 cites W1792090669 @default.
- W1956486503 cites W1792460785 @default.
- W1956486503 cites W1797273806 @default.
- W1956486503 cites W1805989424 @default.
- W1956486503 cites W1817518712 @default.
- W1956486503 cites W1821324646 @default.
- W1956486503 cites W1823502525 @default.
- W1956486503 cites W1828150019 @default.
- W1956486503 cites W1837072983 @default.
- W1956486503 cites W185183492 @default.
- W1956486503 cites W1852637024 @default.
- W1956486503 cites W1856318005 @default.
- W1956486503 cites W1869885415 @default.
- W1956486503 cites W1874547427 @default.
- W1956486503 cites W189298162 @default.
- W1956486503 cites W1894212043 @default.
- W1956486503 cites W1897390225 @default.
- W1956486503 cites W1903775045 @default.
- W1956486503 cites W1912107272 @default.
- W1956486503 cites W1914743657 @default.
- W1956486503 cites W1944753949 @default.
- W1956486503 cites W1964352211 @default.
- W1956486503 cites W1964393999 @default.
- W1956486503 cites W1964434806 @default.
- W1956486503 cites W1964594757 @default.
- W1956486503 cites W1964918855 @default.
- W1956486503 cites W1965749097 @default.
- W1956486503 cites W1965983004 @default.
- W1956486503 cites W1966167135 @default.
- W1956486503 cites W1966926727 @default.
- W1956486503 cites W1967502057 @default.
- W1956486503 cites W1967518399 @default.
- W1956486503 cites W1967600689 @default.
- W1956486503 cites W1968200351 @default.
- W1956486503 cites W1968745789 @default.
- W1956486503 cites W1968750290 @default.