Matches in SemOpenAlex for { <https://semopenalex.org/work/W1956825767> ?p ?o ?g. }
- W1956825767 endingPage "3400" @default.
- W1956825767 startingPage "3392" @default.
- W1956825767 abstract "Twenty-five years after its inception, the genetic engineering of T cells is now a therapeutic modality pursued at an increasing number of medical centers. This immunotherapeutic strategy is predicated on gene transfer technology to instruct T lymphocytes to recognize and reject tumor cells. Chimeric antigen receptors (CARs) are synthetic receptors that mediate antigen recognition, T cell activation, and — in the case of second-generation CARs — costimulation to augment T cell functionality and persistence. We demonstrated over a decade ago that human T cells engineered with a CD19-specific CAR eradicated B cell malignancies in mice. Several phase I clinical trials eventually yielded dramatic results in patients with leukemia or lymphoma, especially acute lymphoblastic leukemia (ALL). This review recounts the milestones of CD19 CAR therapy and summarizes lessons learned from the CD19 paradigm." @default.
- W1956825767 created "2016-06-24" @default.
- W1956825767 creator A5059625599 @default.
- W1956825767 date "2015-09-01" @default.
- W1956825767 modified "2023-10-03" @default.
- W1956825767 title "CAR therapy: the CD19 paradigm" @default.
- W1956825767 cites W118929285 @default.
- W1956825767 cites W1274344746 @default.
- W1956825767 cites W1480489408 @default.
- W1956825767 cites W148516797 @default.
- W1956825767 cites W1490238624 @default.
- W1956825767 cites W1574443686 @default.
- W1956825767 cites W1604141497 @default.
- W1956825767 cites W1624657716 @default.
- W1956825767 cites W1908249423 @default.
- W1956825767 cites W1963522404 @default.
- W1956825767 cites W1964788867 @default.
- W1956825767 cites W1965411082 @default.
- W1956825767 cites W1966542058 @default.
- W1956825767 cites W1967517831 @default.
- W1956825767 cites W1973386538 @default.
- W1956825767 cites W1974559250 @default.
- W1956825767 cites W1979829306 @default.
- W1956825767 cites W1981150156 @default.
- W1956825767 cites W1981302308 @default.
- W1956825767 cites W1981686597 @default.
- W1956825767 cites W1983056774 @default.
- W1956825767 cites W1984287161 @default.
- W1956825767 cites W1985579610 @default.
- W1956825767 cites W2001327683 @default.
- W1956825767 cites W2002132740 @default.
- W1956825767 cites W2003197307 @default.
- W1956825767 cites W2004458954 @default.
- W1956825767 cites W2005354199 @default.
- W1956825767 cites W2010607826 @default.
- W1956825767 cites W2012108097 @default.
- W1956825767 cites W2012694659 @default.
- W1956825767 cites W2014154395 @default.
- W1956825767 cites W2017963255 @default.
- W1956825767 cites W2028460943 @default.
- W1956825767 cites W2028744022 @default.
- W1956825767 cites W2031011895 @default.
- W1956825767 cites W2037036587 @default.
- W1956825767 cites W2037268051 @default.
- W1956825767 cites W2037719060 @default.
- W1956825767 cites W2039721940 @default.
- W1956825767 cites W2044850771 @default.
- W1956825767 cites W2045197676 @default.
- W1956825767 cites W2046562334 @default.
- W1956825767 cites W2047192675 @default.
- W1956825767 cites W2047420649 @default.
- W1956825767 cites W2048154203 @default.
- W1956825767 cites W2051549641 @default.
- W1956825767 cites W2052971969 @default.
- W1956825767 cites W2055820960 @default.
- W1956825767 cites W2057389857 @default.
- W1956825767 cites W2058817033 @default.
- W1956825767 cites W2061728533 @default.
- W1956825767 cites W2064272625 @default.
- W1956825767 cites W2066671159 @default.
- W1956825767 cites W2068302119 @default.
- W1956825767 cites W2074327759 @default.
- W1956825767 cites W2076056289 @default.
- W1956825767 cites W2076991609 @default.
- W1956825767 cites W2078225503 @default.
- W1956825767 cites W2082189475 @default.
- W1956825767 cites W2082708772 @default.
- W1956825767 cites W2084825289 @default.
- W1956825767 cites W2087055812 @default.
- W1956825767 cites W2087209798 @default.
- W1956825767 cites W2089828715 @default.
- W1956825767 cites W2091246599 @default.
- W1956825767 cites W2093065396 @default.
- W1956825767 cites W2093654081 @default.
- W1956825767 cites W2094652659 @default.
- W1956825767 cites W2095491662 @default.
- W1956825767 cites W2099570622 @default.
- W1956825767 cites W2105400883 @default.
- W1956825767 cites W2107806760 @default.
- W1956825767 cites W2107925822 @default.
- W1956825767 cites W2109616567 @default.
- W1956825767 cites W2113802879 @default.
- W1956825767 cites W2118796952 @default.
- W1956825767 cites W2124513722 @default.
- W1956825767 cites W2129702476 @default.
- W1956825767 cites W2130338247 @default.
- W1956825767 cites W2130830673 @default.
- W1956825767 cites W2132747547 @default.
- W1956825767 cites W2134033073 @default.
- W1956825767 cites W2136100686 @default.
- W1956825767 cites W2141410122 @default.
- W1956825767 cites W2143262991 @default.
- W1956825767 cites W2144796561 @default.
- W1956825767 cites W2159304865 @default.
- W1956825767 cites W2160989461 @default.
- W1956825767 cites W2161958391 @default.
- W1956825767 cites W2165984958 @default.
- W1956825767 cites W2166487857 @default.