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- W195693635 abstract "Embryos undergo complicated morphogenetic changes during organogenesis. Detailed characterization of the remodeling will help in elucidating the etiology of the congenital anomalies. The analysis of such changes require the visualization of embryonic structures in three-dimensions (3D). To generate high resolution 3D images through the period of organogenesis, human embryos from the Kyoto Collection at Carnegie stages 13 to 23 were imaged by magnetic resonance imaging (MRI) and with episcopic fluorescence image capture (EFIC) - a novel high resolution histological technique that provides perfectly registered serial 2D images suitable for high fidelity 3D rendering. Embryos were first MRI scanned using a 7T super-conducting magnet, followed by EFIC imaging. Obtained high-resolution images were resectioned digitally in multiple planes, allowing detailed visualization of anatomic structures in the developing embryo. Using these data sets, we constructed a digital atlas, with each stage represented by serial 2D image stacks shown in three orthogonal planes. The Atlas also includes annotations delineating important anatomic structures and developmental milestones, as well as 3D Quicktime movies in different perspectives. This Atlas of the Human Embryo should serve as an invaluable resource for morphologic information of human development, and for studying the etiology of the congenital anomalies." @default.
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- W195693635 date "2008-03-01" @default.
- W195693635 modified "2023-09-27" @default.
- W195693635 title "Digital Atlas of Human Embryonic Development by High Resolution Imaging" @default.
- W195693635 doi "https://doi.org/10.1096/fasebj.22.1_supplement.983.1" @default.
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