FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1956977442> ?p ?o ?g. }

• W1956977442 endingPage "E1201" @default.
• W1956977442 startingPage "E1196" @default.
• W1956977442 abstract "What's known on the subject? and What does the study add? A previous study by Lexander et al. in 2005, using two-dimensional gel electrophoresis, demonstrated the expression of arginase type II in the different anatomical regions of the prostate; however, to date, no study has addressed, using an in vitro approach, the role of arginase isoenzymes in the human prostate. The results of the present study demonstrate that: both arginase isoenzymes, Arg I and Arg II, are expressed in the transition zone of the human prostate; the inhibition of arginase antagonized, to a certain degree, the tension brought about by noradrenaline in isolated human prostate tissue; exposure of human prostate tissue to arginase inhibitors enhanced the local production of cyclic GMP; and inhibition of arginase enzymes in the human prostate may augment the activity of the nitric oxide/cyclicGMP pathway. OBJECTIVE • To investigate the expression of arginase isoenzymes type I (Arg I) and type II (Arg II) in the transition zone of the human prostate and the functional significance of arginase enzymes in the control of prostate smooth muscle. MATERIALS AND METHODS • Human prostate tissue was obtained from male patients who had undergone pelvic surgery. • The expression of Arg I and Arg II was investigated using Western blot analysis. • Using the organ bath technique, the effects of cumulative administration of difluoromethylornithine (DFMO), H-Orn-OH × HCl, H-Ile-OH and N-ω-hydroxy-nor-L-arginine (nor-NOHA; 1 nM–10 µM) on the tension induced by noradrenaline in isolated prostate tissue were assessed. • Tissue strips were also exposed to arginase inhibitors and the production of cyclic GMP was determined. RESULTS • Western blot analysis showed the expression of Arg I and Arg II in the transition zone of the prostate. • The tension induced by noradrenaline was antagonized by the drugs in the following rank order of efficacy: H-Orn-OH × HCl ≥ H-Ile-OH ≥ DFMO > nor-NOHA; however, the maximum reversion of tension recorded ranged from only −25 to −13%. • The enhancement in cyclic GMP production registered in the presence of the arginase inhibitors ranged from four- to 14-fold. CONCLUSIONS • Arg I and Arg II are expressed in the transition zone of the human prostate. • Isometric tension studies and measurement of cyclic GMP showed that inhibition of arginase can reverse, to a certain degree, the tension of human prostate tissue induced by the activation of α-adrenoceptors and enhance the accumulation of cyclic GMP. • Future studies should explore further the role of arginase enzymes in the relaxation mediated by nitric oxide in prostate smooth muscle." @default.
• W1956977442 created "2016-06-24" @default.
• W1956977442 creator A5041727274 @default.
• W1956977442 creator A5074132849 @default.
• W1956977442 creator A5080116321 @default.
• W1956977442 creator A5089325412 @default.
• W1956977442 date "2012-09-27" @default.
• W1956977442 modified "2023-09-23" @default.
• W1956977442 title "Arginase enzymes in the human prostate: expression of arginase isoenzymes and effects of arginase inhibitors on isolated human prostate tissue" @default.
• W1956977442 cites W1842542340 @default.
• W1956977442 cites W1860598036 @default.
• W1956977442 cites W1980852641 @default.
• W1956977442 cites W1984717834 @default.
• W1956977442 cites W1986992071 @default.
• W1956977442 cites W1991078040 @default.
• W1956977442 cites W1991116591 @default.
• W1956977442 cites W1994342338 @default.
• W1956977442 cites W1997370567 @default.
• W1956977442 cites W1997605348 @default.
• W1956977442 cites W1999476415 @default.
• W1956977442 cites W2004962377 @default.
• W1956977442 cites W2006916272 @default.
• W1956977442 cites W2038833973 @default.
• W1956977442 cites W2043218191 @default.
• W1956977442 cites W2045868878 @default.
• W1956977442 cites W2072875643 @default.
• W1956977442 cites W2110073614 @default.
• W1956977442 cites W2115613725 @default.
• W1956977442 cites W2120046557 @default.
• W1956977442 cites W2125031388 @default.
• W1956977442 cites W2133040336 @default.
• W1956977442 cites W2156537912 @default.
• W1956977442 cites W2166130920 @default.
• W1956977442 cites W2339260588 @default.
• W1956977442 doi "https://doi.org/10.1111/j.1464-410x.2012.11529.x" @default.
• W1956977442 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23017122" @default.
• W1956977442 hasPublicationYear "2012" @default.
• W1956977442 type Work @default.
• W1956977442 sameAs 1956977442 @default.
• W1956977442 citedByCount "3" @default.
• W1956977442 countsByYear W19569774422016 @default.
• W1956977442 countsByYear W19569774422019 @default.
• W1956977442 crossrefType "journal-article" @default.
• W1956977442 hasAuthorship W1956977442A5041727274 @default.
• W1956977442 hasAuthorship W1956977442A5074132849 @default.
• W1956977442 hasAuthorship W1956977442A5080116321 @default.
• W1956977442 hasAuthorship W1956977442A5089325412 @default.
• W1956977442 hasConcept C104317684 @default.
• W1956977442 hasConcept C119795356 @default.
• W1956977442 hasConcept C121608353 @default.
• W1956977442 hasConcept C126322002 @default.
• W1956977442 hasConcept C134018914 @default.
• W1956977442 hasConcept C164007495 @default.
• W1956977442 hasConcept C181199279 @default.
• W1956977442 hasConcept C2776235491 @default.
• W1956977442 hasConcept C2776415932 @default.
• W1956977442 hasConcept C2777468819 @default.
• W1956977442 hasConcept C515207424 @default.
• W1956977442 hasConcept C55493867 @default.
• W1956977442 hasConcept C71924100 @default.
• W1956977442 hasConcept C86803240 @default.
• W1956977442 hasConceptScore W1956977442C104317684 @default.
• W1956977442 hasConceptScore W1956977442C119795356 @default.
• W1956977442 hasConceptScore W1956977442C121608353 @default.
• W1956977442 hasConceptScore W1956977442C126322002 @default.
• W1956977442 hasConceptScore W1956977442C134018914 @default.
• W1956977442 hasConceptScore W1956977442C164007495 @default.
• W1956977442 hasConceptScore W1956977442C181199279 @default.
• W1956977442 hasConceptScore W1956977442C2776235491 @default.
• W1956977442 hasConceptScore W1956977442C2776415932 @default.
• W1956977442 hasConceptScore W1956977442C2777468819 @default.
• W1956977442 hasConceptScore W1956977442C515207424 @default.
• W1956977442 hasConceptScore W1956977442C55493867 @default.
• W1956977442 hasConceptScore W1956977442C71924100 @default.
• W1956977442 hasConceptScore W1956977442C86803240 @default.
• W1956977442 hasIssue "11c" @default.
• W1956977442 hasLocation W19569774421 @default.
• W1956977442 hasLocation W19569774422 @default.
• W1956977442 hasOpenAccess W1956977442 @default.
• W1956977442 hasPrimaryLocation W19569774421 @default.
• W1956977442 hasRelatedWork W1967095436 @default.
• W1956977442 hasRelatedWork W1974847931 @default.
• W1956977442 hasRelatedWork W1982094574 @default.
• W1956977442 hasRelatedWork W1985351094 @default.
• W1956977442 hasRelatedWork W2045993936 @default.
• W1956977442 hasRelatedWork W2051886420 @default.
• W1956977442 hasRelatedWork W2053144709 @default.
• W1956977442 hasRelatedWork W2059592631 @default.
• W1956977442 hasRelatedWork W2114207646 @default.
• W1956977442 hasRelatedWork W2168702221 @default.
• W1956977442 hasVolume "110" @default.
• W1956977442 isParatext "false" @default.
• W1956977442 isRetracted "false" @default.
• W1956977442 magId "1956977442" @default.
• W1956977442 workType "article" @default.