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- W1957027480 abstract "Human cytomegalovirus (HCMV) is a recognized cause of disease in the fetus, the allograft recipient and AIDS patients. More recently, it has been recognized as a pathogen for those admitted to intensive care units, for the elderly and for the general population. The epidemiology and molecular and cellular pathology of this virus are summarized to provide an overarching model of pathogenesis, able to account for these varying clinical presentations. In brief, HCMV has the potential to spread in the bloodstream to all organs, but only produces overt disease if the viral load increases to high levels. This is normally prevented by a robust immune response, so that the infected individual usually remains asymptomatic. However, this benefit comes at the cost of committing more and more immunological resources to controlling HCMV with time, so that the overall function of the immune system is impaired. Fortunately, recent progress in developing novel antiviral drugs and vaccines suggests the possibility that the diverse effects of HCMV may soon become controllable at the individual and population level, respectively. Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd." @default.
- W1957027480 created "2016-06-24" @default.
- W1957027480 creator A5027717859 @default.
- W1957027480 creator A5064687527 @default.
- W1957027480 creator A5084236065 @default.
- W1957027480 date "2014-12-11" @default.
- W1957027480 modified "2023-10-13" @default.
- W1957027480 title "The pathogenesis of human cytomegalovirus" @default.
- W1957027480 cites W1515281699 @default.
- W1957027480 cites W1536097482 @default.
- W1957027480 cites W1536477464 @default.
- W1957027480 cites W1596555978 @default.
- W1957027480 cites W1638089104 @default.
- W1957027480 cites W172255198 @default.
- W1957027480 cites W1899668122 @default.
- W1957027480 cites W1963943606 @default.
- W1957027480 cites W1964136591 @default.
- W1957027480 cites W1969171949 @default.
- W1957027480 cites W1971742580 @default.
- W1957027480 cites W1979011182 @default.
- W1957027480 cites W1983477252 @default.
- W1957027480 cites W1983923750 @default.
- W1957027480 cites W1988358627 @default.
- W1957027480 cites W1989700483 @default.
- W1957027480 cites W1991308016 @default.
- W1957027480 cites W1993163623 @default.
- W1957027480 cites W1996688582 @default.
- W1957027480 cites W1996960673 @default.
- W1957027480 cites W1999421885 @default.
- W1957027480 cites W1999722506 @default.
- W1957027480 cites W2005017965 @default.
- W1957027480 cites W2007134676 @default.
- W1957027480 cites W2020381478 @default.
- W1957027480 cites W2020586045 @default.
- W1957027480 cites W2029345949 @default.
- W1957027480 cites W2034822577 @default.
- W1957027480 cites W2039648443 @default.
- W1957027480 cites W2041959641 @default.
- W1957027480 cites W2043426227 @default.
- W1957027480 cites W2046433603 @default.
- W1957027480 cites W2051541406 @default.
- W1957027480 cites W2052667644 @default.
- W1957027480 cites W2056774192 @default.
- W1957027480 cites W2059937450 @default.
- W1957027480 cites W2060554651 @default.
- W1957027480 cites W2061788089 @default.
- W1957027480 cites W2062717261 @default.
- W1957027480 cites W2064796142 @default.
- W1957027480 cites W2066455030 @default.
- W1957027480 cites W2066964567 @default.
- W1957027480 cites W2068604359 @default.
- W1957027480 cites W2072562300 @default.
- W1957027480 cites W2073368255 @default.
- W1957027480 cites W2073898372 @default.
- W1957027480 cites W2074715606 @default.
- W1957027480 cites W2078011987 @default.
- W1957027480 cites W2080426618 @default.
- W1957027480 cites W2082966693 @default.
- W1957027480 cites W2084072271 @default.
- W1957027480 cites W2085838568 @default.
- W1957027480 cites W2092640232 @default.
- W1957027480 cites W2096963698 @default.
- W1957027480 cites W2101983446 @default.
- W1957027480 cites W2102254194 @default.
- W1957027480 cites W2103794276 @default.
- W1957027480 cites W2104124112 @default.
- W1957027480 cites W2105193766 @default.
- W1957027480 cites W2106759581 @default.
- W1957027480 cites W2107655439 @default.
- W1957027480 cites W2114972655 @default.
- W1957027480 cites W2121749962 @default.
- W1957027480 cites W2124734530 @default.
- W1957027480 cites W2130696479 @default.
- W1957027480 cites W2131924520 @default.
- W1957027480 cites W2133392557 @default.
- W1957027480 cites W2133963802 @default.
- W1957027480 cites W2135275277 @default.
- W1957027480 cites W2137333397 @default.
- W1957027480 cites W2139783252 @default.
- W1957027480 cites W2142682198 @default.
- W1957027480 cites W2143551386 @default.
- W1957027480 cites W2146339219 @default.
- W1957027480 cites W2154418144 @default.
- W1957027480 cites W2162778062 @default.
- W1957027480 cites W2164613060 @default.
- W1957027480 cites W2169900672 @default.
- W1957027480 cites W2170651190 @default.
- W1957027480 cites W2171623668 @default.
- W1957027480 cites W2171944774 @default.
- W1957027480 cites W2312658128 @default.
- W1957027480 cites W2331879273 @default.
- W1957027480 cites W3023296822 @default.
- W1957027480 cites W4207025476 @default.
- W1957027480 cites W4232689224 @default.
- W1957027480 doi "https://doi.org/10.1002/path.4437" @default.
- W1957027480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25205255" @default.
- W1957027480 hasPublicationYear "2014" @default.
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