FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1957116541> ?p ?o ?g. }

• W1957116541 endingPage "e0135141" @default.
• W1957116541 startingPage "e0135141" @default.
• W1957116541 abstract "Human epithelial, endothelial and PMA-differentiated THP-1 cell lines were used as model systems to study the transcriptional regulation of the human FCGRT gene encoding the alpha chain of hFcRn. The data obtained from site-directed mutagenesis in transient transfection experiments indicate that the Sp1 sites at positions -641, -635, and -313, CF1/YY1 elements at positions -586 and -357, and the AP-1 motif at -276 within the-660/-233 fragment of the human FCGRT promoter (hFCGRT) participate in the regulation of human FCGRT in all selected cell lines. However, their individual contribution to promoter activity is not equivalent. The Sp1 binding site at -313 and the AP-1 site at -276 are critical for the activity of the hFCGRT promoter in epithelial and endothelial cells. Moreover, the CF1/YY1 site at -586 in differentiated THP-1 cells, plays an essential role in the transcriptional activity of the promoter. In addition, the C/EBPbeta binding site at -497 of the hFCGRT promoter in epithelial and endothelial cells, and the C/EBPbeta motif located at -497 and -233 within the hFCGRT promoter in differentiated THP-1 cells may function as positive regulatory sequences in response to LPS or PMA stimulation. EMSA and supershift analyses showed that the functionally identified binding motifs in the hFCGRT promoter were able to specifically interact with their corresponding (Sp1, Sp2, Sp3, c-Fos, c-Jun, YY1, and C/EBPbeta or C/EBPdelta) transcription factors (TFs), suggesting their possible involvement in the regulation of the human FCGRT gene expression." @default.
• W1957116541 created "2016-06-24" @default.
• W1957116541 creator A5049330429 @default.
• W1957116541 date "2015-08-07" @default.
• W1957116541 modified "2023-09-30" @default.
• W1957116541 title "Analysis of Response Elements Involved in the Regulation of the Human Neonatal Fc Receptor Gene (FCGRT)" @default.
• W1957116541 cites W1555726473 @default.
• W1957116541 cites W1574577460 @default.
• W1957116541 cites W1581464536 @default.
• W1957116541 cites W1807443381 @default.
• W1957116541 cites W1954133219 @default.
• W1957116541 cites W1967874097 @default.
• W1957116541 cites W1978367617 @default.
• W1957116541 cites W1996362292 @default.
• W1957116541 cites W2002593667 @default.
• W1957116541 cites W2003476770 @default.
• W1957116541 cites W2004181770 @default.
• W1957116541 cites W2006658260 @default.
• W1957116541 cites W2016730049 @default.
• W1957116541 cites W2020107583 @default.
• W1957116541 cites W2020624387 @default.
• W1957116541 cites W2024972268 @default.
• W1957116541 cites W2027014013 @default.
• W1957116541 cites W2035464330 @default.
• W1957116541 cites W2042041059 @default.
• W1957116541 cites W2045624879 @default.
• W1957116541 cites W2049862742 @default.
• W1957116541 cites W2050372398 @default.
• W1957116541 cites W2060544357 @default.
• W1957116541 cites W2066664309 @default.
• W1957116541 cites W2075689961 @default.
• W1957116541 cites W2078282138 @default.
• W1957116541 cites W2082496903 @default.
• W1957116541 cites W2092960801 @default.
• W1957116541 cites W2098768418 @default.
• W1957116541 cites W2099960599 @default.
• W1957116541 cites W2100195091 @default.
• W1957116541 cites W2106100082 @default.
• W1957116541 cites W2109264608 @default.
• W1957116541 cites W2111462418 @default.
• W1957116541 cites W2114995793 @default.
• W1957116541 cites W2120599736 @default.
• W1957116541 cites W2122301622 @default.
• W1957116541 cites W2138771248 @default.
• W1957116541 cites W2155188603 @default.
• W1957116541 cites W2162907283 @default.
• W1957116541 cites W2169414032 @default.
• W1957116541 cites W4235459301 @default.
• W1957116541 cites W4293247451 @default.
• W1957116541 doi "https://doi.org/10.1371/journal.pone.0135141" @default.
• W1957116541 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4587857" @default.
• W1957116541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26418416" @default.
• W1957116541 hasPublicationYear "2015" @default.
• W1957116541 type Work @default.
• W1957116541 sameAs 1957116541 @default.
• W1957116541 citedByCount "7" @default.
• W1957116541 countsByYear W19571165412016 @default.
• W1957116541 countsByYear W19571165412019 @default.
• W1957116541 countsByYear W19571165412021 @default.
• W1957116541 countsByYear W19571165412022 @default.
• W1957116541 crossrefType "journal-article" @default.
• W1957116541 hasAuthorship W1957116541A5049330429 @default.
• W1957116541 hasBestOaLocation W19571165411 @default.
• W1957116541 hasConcept C101762097 @default.
• W1957116541 hasConcept C104317684 @default.
• W1957116541 hasConcept C107824862 @default.
• W1957116541 hasConcept C132376346 @default.
• W1957116541 hasConcept C150194340 @default.
• W1957116541 hasConcept C153911025 @default.
• W1957116541 hasConcept C165864922 @default.
• W1957116541 hasConcept C27153228 @default.
• W1957116541 hasConcept C54009773 @default.
• W1957116541 hasConcept C54355233 @default.
• W1957116541 hasConcept C62944979 @default.
• W1957116541 hasConcept C81885089 @default.
• W1957116541 hasConcept C86339819 @default.
• W1957116541 hasConcept C86803240 @default.
• W1957116541 hasConcept C95444343 @default.
• W1957116541 hasConceptScore W1957116541C101762097 @default.
• W1957116541 hasConceptScore W1957116541C104317684 @default.
• W1957116541 hasConceptScore W1957116541C107824862 @default.
• W1957116541 hasConceptScore W1957116541C132376346 @default.
• W1957116541 hasConceptScore W1957116541C150194340 @default.
• W1957116541 hasConceptScore W1957116541C153911025 @default.
• W1957116541 hasConceptScore W1957116541C165864922 @default.
• W1957116541 hasConceptScore W1957116541C27153228 @default.
• W1957116541 hasConceptScore W1957116541C54009773 @default.
• W1957116541 hasConceptScore W1957116541C54355233 @default.
• W1957116541 hasConceptScore W1957116541C62944979 @default.
• W1957116541 hasConceptScore W1957116541C81885089 @default.
• W1957116541 hasConceptScore W1957116541C86339819 @default.
• W1957116541 hasConceptScore W1957116541C86803240 @default.
• W1957116541 hasConceptScore W1957116541C95444343 @default.
• W1957116541 hasIssue "8" @default.
• W1957116541 hasLocation W19571165411 @default.
• W1957116541 hasLocation W19571165412 @default.
• W1957116541 hasLocation W19571165413 @default.
• W1957116541 hasOpenAccess W1957116541 @default.

• next