FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1957186413> ?p ?o ?g. }

• W1957186413 endingPage "344" @default.
• W1957186413 startingPage "329" @default.
• W1957186413 abstract "Obesity has epidemic proportions in Western societies and, because of its significant association with morbidity and mortality, is a major public health issue. Excessive daytime sleepiness (EDS) and fatigue (tiredness without increased sleep propensity)--which have been associated with obesity--have a significant impact on individual well-being and public safety. In this article, we review data that challenge the belief that sleep apnea and sleep disruption per se are the primary determinants of obesity-related daytime sleepiness and fatigue. Specifically, it appears that obesity per se is associated with objective and subjective daytime sleepiness compared to normal-weight controls regardless of sleep apnea and sleep loss. Indeed, obese patients without sleep apnea are sleepier compared to nonobese controls whereas within the morbidly obese, those who have high sleep efficiency at night are sleepier than those who have low sleep efficiency. In addition, in recent studies based on large random samples of the general population, the primary determinants of subjective EDS were depression and metabolic disturbances, that is, obesity/diabetes, and not sleep apnea or objective sleep disruption. Furthermore, sleepiness and fatigue are very prevalent in conditions associated with insulin resistance, for instance, the polycystic ovary syndrome (PCOS), independently of sleep apnea or obesity, or in conditions of insufficient physical activity. On the basis of these data, we propose that obesity-related objective daytime sleepiness and fatigue are associated primarily with metabolic and psychological factors and less with sleep apnea and sleep disruption per se. Furthermore, we suggest that objective sleepiness is primarily related to metabolic factors, whereas fatigue appears to be related to psychological distress. Finally, based on data from studies in normal controls and patients with sleep disorders, we propose that the interaction of the hypothalamic-pituitary-adrenal (HPA) axis and proinflammatory cytokines determines the level of sleep/arousal within the 24-h cycle, that is, hypercortisolemia plus hypercytokinemia is associated with low sleep efficiency and fatigue, whereas eucortisolemia or hypocortisolemia plus hypercytokinemia is associated with high sleep efficiency and objective sleepiness." @default.
• W1957186413 created "2016-06-24" @default.
• W1957186413 creator A5046164327 @default.
• W1957186413 creator A5059575944 @default.
• W1957186413 creator A5073483206 @default.
• W1957186413 date "2006-11-01" @default.
• W1957186413 modified "2023-10-11" @default.
• W1957186413 title "Obesity-Related Sleepiness and Fatigue: The Role of the Stress System and Cytokines" @default.
• W1957186413 cites W127750747 @default.
• W1957186413 cites W131102238 @default.
• W1957186413 cites W1427890859 @default.
• W1957186413 cites W1714259827 @default.
• W1957186413 cites W1715223110 @default.
• W1957186413 cites W1823065994 @default.
• W1957186413 cites W1880976932 @default.
• W1957186413 cites W1965011825 @default.
• W1957186413 cites W1969822000 @default.
• W1957186413 cites W1970138464 @default.
• W1957186413 cites W1975390269 @default.
• W1957186413 cites W1976966411 @default.
• W1957186413 cites W1987480121 @default.
• W1957186413 cites W1994381724 @default.
• W1957186413 cites W1996692474 @default.
• W1957186413 cites W1996989437 @default.
• W1957186413 cites W2007651172 @default.
• W1957186413 cites W2009194627 @default.
• W1957186413 cites W2015417570 @default.
• W1957186413 cites W2016192465 @default.
• W1957186413 cites W2017132921 @default.
• W1957186413 cites W2018590161 @default.
• W1957186413 cites W2019703818 @default.
• W1957186413 cites W2022139094 @default.
• W1957186413 cites W2030390156 @default.
• W1957186413 cites W2033916720 @default.
• W1957186413 cites W2045058491 @default.
• W1957186413 cites W2060583623 @default.
• W1957186413 cites W2069272625 @default.
• W1957186413 cites W2070132763 @default.
• W1957186413 cites W2072065348 @default.
• W1957186413 cites W2073110258 @default.
• W1957186413 cites W2090140151 @default.
• W1957186413 cites W2093240006 @default.
• W1957186413 cites W2099915725 @default.
• W1957186413 cites W2109610174 @default.
• W1957186413 cites W2119213758 @default.
• W1957186413 cites W2121436198 @default.
• W1957186413 cites W2124052130 @default.
• W1957186413 cites W2124953491 @default.
• W1957186413 cites W2128103058 @default.
• W1957186413 cites W2136189569 @default.
• W1957186413 cites W2143809989 @default.
• W1957186413 cites W2143831791 @default.
• W1957186413 cites W2145833772 @default.
• W1957186413 cites W2148345618 @default.
• W1957186413 cites W2153762265 @default.
• W1957186413 cites W2158187071 @default.
• W1957186413 cites W2160244351 @default.
• W1957186413 cites W2171783792 @default.
• W1957186413 cites W2172000602 @default.
• W1957186413 cites W2260387628 @default.
• W1957186413 cites W2264784497 @default.
• W1957186413 cites W2323643729 @default.
• W1957186413 cites W2333343699 @default.
• W1957186413 cites W2396643199 @default.
• W1957186413 cites W2411974143 @default.
• W1957186413 cites W2418692749 @default.
• W1957186413 cites W2916596946 @default.
• W1957186413 cites W4230221889 @default.
• W1957186413 cites W4232884457 @default.
• W1957186413 cites W4237579429 @default.
• W1957186413 cites W4241512768 @default.
• W1957186413 cites W4243994088 @default.
• W1957186413 cites W4244653448 @default.
• W1957186413 cites W4245065923 @default.
• W1957186413 cites W4246099984 @default.
• W1957186413 cites W4246131963 @default.
• W1957186413 cites W4247356241 @default.
• W1957186413 cites W4248256031 @default.
• W1957186413 cites W4248530879 @default.
• W1957186413 cites W4250130254 @default.
• W1957186413 cites W4250609742 @default.
• W1957186413 cites W4252978893 @default.
• W1957186413 cites W4255475557 @default.
• W1957186413 doi "https://doi.org/10.1196/annals.1367.023" @default.
• W1957186413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17148748" @default.
• W1957186413 hasPublicationYear "2006" @default.
• W1957186413 type Work @default.
• W1957186413 sameAs 1957186413 @default.
• W1957186413 citedByCount "192" @default.
• W1957186413 countsByYear W19571864132012 @default.
• W1957186413 countsByYear W19571864132013 @default.
• W1957186413 countsByYear W19571864132014 @default.
• W1957186413 countsByYear W19571864132015 @default.
• W1957186413 countsByYear W19571864132016 @default.
• W1957186413 countsByYear W19571864132017 @default.
• W1957186413 countsByYear W19571864132018 @default.
• W1957186413 countsByYear W19571864132019 @default.
• W1957186413 countsByYear W19571864132020 @default.

• next