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- W1957300002 endingPage "698" @default.
- W1957300002 startingPage "690" @default.
- W1957300002 abstract "Differentiated thyroid cancer is the most common endocrine malignancy, and its incidence has been rising rapidly over the past 10 years. Although most patients with this disease have an excellent prognosis, a subset develops a more aggressive disease phenotype refractory to conventional therapies. Until recently, there was no effective therapy for these patients. With increasing knowledge of the molecular pathogenesis of thyroid cancer, novel targeted therapies are being developed for this group of patients. Sorafenib and lenvatinib, small-molecule multikinase inhibitors, were approved for the treatment of progressive, symptomatic, radioactive iodine refractory, advanced differentiated thyroid cancer in 2013 and 2015, respectively. This represents a major innovation in the therapy of patients with advanced thyroid cancer. However, these therapies still have many limitations and further research needs to be pursued with the ultimate goal of providing safe and effective personalized therapy for patients with advanced thyroid cancer." @default.
- W1957300002 created "2016-06-24" @default.
- W1957300002 creator A5031405616 @default.
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- W1957300002 creator A5061285204 @default.
- W1957300002 creator A5069923958 @default.
- W1957300002 creator A5077741246 @default.
- W1957300002 date "2015-09-01" @default.
- W1957300002 modified "2023-10-13" @default.
- W1957300002 title "Targeted therapies in advanced differentiated thyroid cancer" @default.
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