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- W1957377539 abstract "The condensation of 1,5-diphenylpyrrolidine-2,4-dione (1) with the carboxyl compounds 2a-f afforded the corresponding 3-arylidene-1,5-diphenylpyrrolidine-2,4-diones 3a-f. Reaction of the parent compound 1 with isatin (4) yielded the condensation product 5 in an acidic medium, whereas compound 6 was obtained in an alkaline medium. The condensation of the primary amines 7a-f with compound 1 afforded the corresponding 4-substituted amino-1,5-diphenyl-delta 3-pyrrolin-2-ones 8a-f. All the compounds synthesized were screened for their antimicrobial activity, and four compounds were selected for screening for their antineoplastic activity. The compounds tested showed both antimicrobial and antineoplastic activities." @default.
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- W1957377539 date "2010-05-18" @default.
- W1957377539 modified "2023-09-26" @default.
- W1957377539 title "ChemInform Abstract: Synthesis of Some 3- and 4-Substituted 1,5-Diphenylpyrrolidine-2,4-diones as Potential Antimicrobial and Antineoplastic Agents. Reactions with Tetramic Acid. Part 5." @default.
- W1957377539 cites W2953036843 @default.
- W1957377539 doi "https://doi.org/10.1002/chin.200248116" @default.
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