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- W19577079 abstract "This chapter presents advanced studies on T-memory cells primed to histoincompatible cells. In one-way mixed lymphocyte culture, the following properties of T-memory cells primed in vitro to histoincompatible cells has been found: (1) the memory cells respond promptly to the original stimulator cells, (2) in secondary MLC, they are non-responsive to the T mitogens phytohemagglutinin (PHA) and Con-A, and (3) they are (low level) cytotoxic to relevant allogeneic target cells in vitro. The non-reactivity of T memory cells to the T mitogens was further examined in some studies by stimulating mouse spleen T cells with PHA or Con-A, by the removal of the mitogen responsive cells (blasts), by one-g velocity sedimentation, and by re-stimulating the remaining lymphocytes by the mitogens or in the MLC. On testing the ability of nonprimed versus primed mouse T cells to respond to UV-killed cells and to histocompatibility antigen preparations, it was found that while nonprimed T cells did not respond, the in vitro primed cells did." @default.
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- W19577079 date "1976-01-01" @default.
- W19577079 modified "2023-10-14" @default.
- W19577079 title "FURTHER STUDIES ON T-MEMORY CELLS PRIMED TO HISTOINCOMPATIBLE CELLS" @default.
- W19577079 doi "https://doi.org/10.1016/b978-0-12-233750-5.50097-x" @default.
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