FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1958001693> ?p ?o ?g. }

• W1958001693 endingPage "574" @default.
• W1958001693 startingPage "559" @default.
• W1958001693 abstract "We report here the first structure of a member of the immunoglobulin A protease (IgAP) family at 1.75-A resolution. This protease is a founding member of the type V (autotransporter) secretion system and is considered a virulence determinant among the bacteria expressing the enzyme. The structure of the enzyme fits that of a classic autotransporter in which several unique domains necessary for protein function are appended to a central, 100-A-long beta-helical domain. The N-terminal domain of the IgAP is found to possess a chymotrypsin-like fold. However, this catalytic domain contains a unique loop D that extends over the active site acting as a lid, gating substrate access. The data presented provide a structural basis for the known ability of IgAPs to cleave only the proline/serine/threonine-rich hinge peptide unique to IgA1 (isotype 1) in the context of the intact fold of the immunoglobulin. Based upon the structural data, as well as molecular modeling, a model suggesting that the unique extended loop D in this IgAP sterically occludes the active-site binding cleft in the absence of immunoglobulin binding is presented. Only in the context of binding of the IgA1-Fc domain in a valley formed between the N-terminal protease domain and another domain appended to the beta-helix spine (domain 2) is the lid stabilized in an open conformation. The stabilization of this open conformation through Fc association subsequently allows access of the hinge peptide to the active site, resulting in recognition and cleavage of the substrate." @default.
• W1958001693 created "2016-06-24" @default.
• W1958001693 creator A5071697935 @default.
• W1958001693 creator A5071719000 @default.
• W1958001693 creator A5077674430 @default.
• W1958001693 creator A5086816733 @default.
• W1958001693 date "2009-06-01" @default.
• W1958001693 modified "2023-10-17" @default.
• W1958001693 title "Active-Site Gating Regulates Substrate Selectivity in a Chymotrypsin-Like Serine Protease" @default.
• W1958001693 cites W1503488066 @default.
• W1958001693 cites W1519586955 @default.
• W1958001693 cites W1539796472 @default.
• W1958001693 cites W1591943330 @default.
• W1958001693 cites W1620881780 @default.
• W1958001693 cites W173669577 @default.
• W1958001693 cites W1901866440 @default.
• W1958001693 cites W1945014753 @default.
• W1958001693 cites W1967966451 @default.
• W1958001693 cites W1968578852 @default.
• W1958001693 cites W1969547178 @default.
• W1958001693 cites W1976996080 @default.
• W1958001693 cites W1980397617 @default.
• W1958001693 cites W1980640496 @default.
• W1958001693 cites W1981302916 @default.
• W1958001693 cites W1985917720 @default.
• W1958001693 cites W1986191025 @default.
• W1958001693 cites W1991192668 @default.
• W1958001693 cites W1996607909 @default.
• W1958001693 cites W2001641653 @default.
• W1958001693 cites W2003046928 @default.
• W1958001693 cites W2004091546 @default.
• W1958001693 cites W2005477941 @default.
• W1958001693 cites W2006515739 @default.
• W1958001693 cites W2014514391 @default.
• W1958001693 cites W2014614175 @default.
• W1958001693 cites W2019283439 @default.
• W1958001693 cites W2022963781 @default.
• W1958001693 cites W2038840577 @default.
• W1958001693 cites W2045476844 @default.
• W1958001693 cites W2054572399 @default.
• W1958001693 cites W2057280776 @default.
• W1958001693 cites W2060342018 @default.
• W1958001693 cites W2065283382 @default.
• W1958001693 cites W2066709456 @default.
• W1958001693 cites W2067921100 @default.
• W1958001693 cites W2067949684 @default.
• W1958001693 cites W2069616560 @default.
• W1958001693 cites W2076895093 @default.
• W1958001693 cites W2078946709 @default.
• W1958001693 cites W2082027528 @default.
• W1958001693 cites W2083461264 @default.
• W1958001693 cites W2100128272 @default.
• W1958001693 cites W2104830972 @default.
• W1958001693 cites W2106882534 @default.
• W1958001693 cites W2107005517 @default.
• W1958001693 cites W2107875000 @default.
• W1958001693 cites W2112393035 @default.
• W1958001693 cites W2112743424 @default.
• W1958001693 cites W2113442468 @default.
• W1958001693 cites W2116203390 @default.
• W1958001693 cites W2119300581 @default.
• W1958001693 cites W2119557232 @default.
• W1958001693 cites W2123383736 @default.
• W1958001693 cites W2123871313 @default.
• W1958001693 cites W2129140874 @default.
• W1958001693 cites W2130726371 @default.
• W1958001693 cites W2137015675 @default.
• W1958001693 cites W2137917644 @default.
• W1958001693 cites W2137955461 @default.
• W1958001693 cites W2144081223 @default.
• W1958001693 cites W2149163736 @default.
• W1958001693 cites W2157362884 @default.
• W1958001693 cites W2161464792 @default.
• W1958001693 cites W2161534369 @default.
• W1958001693 cites W2162244749 @default.
• W1958001693 cites W2163341755 @default.
• W1958001693 cites W2163351388 @default.
• W1958001693 cites W2163462520 @default.
• W1958001693 cites W2166498153 @default.
• W1958001693 cites W2170421654 @default.
• W1958001693 cites W2227664617 @default.
• W1958001693 cites W25059625 @default.
• W1958001693 cites W36310178 @default.
• W1958001693 cites W4205949518 @default.
• W1958001693 doi "https://doi.org/10.1016/j.jmb.2009.04.041" @default.
• W1958001693 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2720633" @default.
• W1958001693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19393662" @default.
• W1958001693 hasPublicationYear "2009" @default.
• W1958001693 type Work @default.
• W1958001693 sameAs 1958001693 @default.
• W1958001693 citedByCount "68" @default.
• W1958001693 countsByYear W19580016932012 @default.
• W1958001693 countsByYear W19580016932013 @default.
• W1958001693 countsByYear W19580016932014 @default.
• W1958001693 countsByYear W19580016932015 @default.
• W1958001693 countsByYear W19580016932016 @default.
• W1958001693 countsByYear W19580016932017 @default.
• W1958001693 countsByYear W19580016932018 @default.

• next