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• W1958049072 endingPage "2097" @default.
• W1958049072 startingPage "2093" @default.
• W1958049072 abstract "A negative regulatory element present in the human papillomavirus type 16 genome has been characterized. Deletion analysis has localized the 5' end of the element to the late region of the genome at the extreme 3' end of the coding region of the L1 open reading frame, around the L1 stop codon, with the element extending into the L1 3' untranslated region. For the cell lines used, the element's function was independent of cell type, tissue, or species of origin, unlike papillomavirus infection, which is very dependent on such factors. By using an mRNA decay assay, we have determined that polyadenylated RNA containing the element is much less stable than polyadenylated RNA lacking the element. This indicates that the element acts as an mRNA instability element. The significance of A-rich, GU-rich, and AUG-rich sequences for the functioning of this human papillomavirus type 16 instability element is discussed." @default.
• W1958049072 created "2016-06-24" @default.
• W1958049072 creator A5002496378 @default.
• W1958049072 creator A5033597062 @default.
• W1958049072 creator A5036675380 @default.
• W1958049072 date "1991-04-01" @default.
• W1958049072 modified "2023-10-17" @default.
• W1958049072 title "A negative regulatory element in the human papillomavirus type 16 genome acts at the level of late mRNA stability" @default.
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• W1958049072 doi "https://doi.org/10.1128/jvi.65.4.2093-2097.1991" @default.
• W1958049072 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/240071" @default.
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