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- W1958183000 abstract "The rodent pineal organ transduces a photoneural input into a hormonal output. This photoneuroendocrine transduction leads to highly elevated levels of the hormone melatonin at night-time which serves as a message for darkness. The melatonin rhythm depends on transcriptional, translational and posttranslational regulation of the arylalkylamine-N-acetyltransferase, the key enzyme of melatonin biosynthesis. These regulatory mechanisms are fundamentally linked to two second messenger systems, namely the cAMP- and the Ca(2+)-signal transduction pathways. Our data gained by molecular biology, immunohistochemistry and single-cell imaging demonstrate a time- and substance-specific activation of these signaling pathways and provide a framework for the understanding of the complex signal transduction cascades in the rodent pineal gland which in concert not only regulate the basic profile but also fine-tune the circadian rhythm in melatonin synthesis." @default.
- W1958183000 created "2016-06-24" @default.
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- W1958183000 date "2002-01-01" @default.
- W1958183000 modified "2023-10-15" @default.
- W1958183000 title "Signal Transduction in The Rodent Pineal Organ" @default.
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- W1958183000 doi "https://doi.org/10.1007/0-306-46814-x_14" @default.
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