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- W1958354013 abstract "Serious concerns have been expressed about potential risks of manufactured TiO2NPs. In this research, toxicity of nanoparticulate and bulk TiO2 were examined to the earthworm Pheretima hawayana. The 24-h median lethal concentration (LC50) and sublethal endpoints were assessed. Both NPs and their bulk counterparts were toxic. The 24-h LC50 for TiO2NPs (145.36 mg kg(-1)) was highly toxic than that of bulk TiO2 (357.77 mg kg(-1)). The aim of the present work is to evaluate the suitability of P. hawayana and its biochemical responses to be used as a bioindicator organism and biomarkers of TiO2 toxicity. Earthworms were exposed to three sublethal concentrations of TiO2NPs (1, 10 and 100 µg kg(-1)) for 28 days to test acetylcholinesterase (AChE), antioxidant enzymes (superoxide dismutase: SOD and catalase: CAT) activities and MDA content. The response of the antioxidant enzymes combined with AChE inhibition and MDA accumulation indicated that TiO2NPs could induce significant impairments to the earthworms at the actual environment tested concentrations. The results pointed out the high sensitivity of the antioxidant and oxidative stress related responses to TiO2NPs exposure, demonstrating their usefulness in environmental monitoring and risk assessment. The study highlights also the usefulness of earthworm P. hawayana as potential bioindicator species for assessing the risk of nanoparticles environmental contamination." @default.
- W1958354013 created "2016-06-24" @default.
- W1958354013 creator A5026509121 @default.
- W1958354013 date "2015-12-01" @default.
- W1958354013 modified "2023-10-18" @default.
- W1958354013 title "Neurotoxicity and biochemical responses in the earthworm Pheretima hawayana exposed to TiO2NPs" @default.
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- W1958354013 doi "https://doi.org/10.1016/j.ecoenv.2015.09.010" @default.
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