FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1958572105> ?p ?o ?g. }

• W1958572105 endingPage "e0131073" @default.
• W1958572105 startingPage "e0131073" @default.
• W1958572105 abstract "T lymphocytes from many patients with systemic lupus erythematosus (SLE) express decreased levels of the T cell receptor (TCR)-associated CD3 zeta (ζ) signaling chain, a feature directly linked to their abnormal phenotype and function. Reduced mRNA expression partly due to defective alternative splicing, contributes to the reduced expression of CD3ζ chain. We previously identified by oligonucleotide pulldown and mass spectrometry approaches, the serine arginine-rich splicing factor 1 (SRSF1) binding to the 3' untranslated region (UTR) of CD3ζ mRNA. We showed that SRSF1 regulates alternative splicing of the 3'UTR of CD3ζ to promote expression of the normal full length 3`UTR over an unstable splice variant in human T cells. In this study we show that SRSF1 regulates transcriptional activation of CD3ζ. Specifically, overexpression and silencing of SRSF1 respectively increases and decreases CD3ζ total mRNA and protein expression in Jurkat and primary T cells. Using promoter-luciferase assays, we show that SRSF1 enhances transcriptional activity of the CD3ζ promoter in a dose dependent manner. Chromatin immunoprecipitation assays show that SRSF1 is recruited to the CD3ζ promoter. These results indicate that SRSF1 contributes to transcriptional activation of CD3ζ. Thus our study identifies a novel mechanism whereby SRSF1 regulates CD3ζ expression in human T cells and may contribute to the T cell defect in SLE." @default.
• W1958572105 created "2016-06-24" @default.
• W1958572105 creator A5024787206 @default.
• W1958572105 creator A5027542245 @default.
• W1958572105 creator A5031122008 @default.
• W1958572105 creator A5059552004 @default.
• W1958572105 creator A5066493053 @default.
• W1958572105 date "2015-07-02" @default.
• W1958572105 modified "2023-10-16" @default.
• W1958572105 title "Serine Arginine-Rich Splicing Factor 1 (SRSF1) Contributes to the Transcriptional Activation of CD3ζ in Human T Cells" @default.
• W1958572105 cites W1621189487 @default.
• W1958572105 cites W1930205043 @default.
• W1958572105 cites W1973492214 @default.
• W1958572105 cites W1988643985 @default.
• W1958572105 cites W1990414704 @default.
• W1958572105 cites W1995771965 @default.
• W1958572105 cites W1996505914 @default.
• W1958572105 cites W1996892555 @default.
• W1958572105 cites W2006484928 @default.
• W1958572105 cites W2016127179 @default.
• W1958572105 cites W2025717782 @default.
• W1958572105 cites W2030596663 @default.
• W1958572105 cites W2035696869 @default.
• W1958572105 cites W2043912021 @default.
• W1958572105 cites W2052561585 @default.
• W1958572105 cites W2074524976 @default.
• W1958572105 cites W2076762468 @default.
• W1958572105 cites W2079235313 @default.
• W1958572105 cites W2091834996 @default.
• W1958572105 cites W2093220086 @default.
• W1958572105 cites W2095117277 @default.
• W1958572105 cites W2097111343 @default.
• W1958572105 cites W2103695683 @default.
• W1958572105 cites W2105078368 @default.
• W1958572105 cites W2109936378 @default.
• W1958572105 cites W2109962448 @default.
• W1958572105 cites W2112917273 @default.
• W1958572105 cites W2138647063 @default.
• W1958572105 cites W2146203649 @default.
• W1958572105 cites W2160910689 @default.
• W1958572105 cites W2163822663 @default.
• W1958572105 cites W2166803308 @default.
• W1958572105 cites W2168888155 @default.
• W1958572105 cites W2607741101 @default.
• W1958572105 cites W4292232933 @default.
• W1958572105 cites W4313333709 @default.
• W1958572105 doi "https://doi.org/10.1371/journal.pone.0131073" @default.
• W1958572105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4489909" @default.
• W1958572105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26134847" @default.
• W1958572105 hasPublicationYear "2015" @default.
• W1958572105 type Work @default.
• W1958572105 sameAs 1958572105 @default.
• W1958572105 citedByCount "13" @default.
• W1958572105 countsByYear W19585721052016 @default.
• W1958572105 countsByYear W19585721052018 @default.
• W1958572105 countsByYear W19585721052020 @default.
• W1958572105 countsByYear W19585721052021 @default.
• W1958572105 countsByYear W19585721052022 @default.
• W1958572105 countsByYear W19585721052023 @default.
• W1958572105 crossrefType "journal-article" @default.
• W1958572105 hasAuthorship W1958572105A5024787206 @default.
• W1958572105 hasAuthorship W1958572105A5027542245 @default.
• W1958572105 hasAuthorship W1958572105A5031122008 @default.
• W1958572105 hasAuthorship W1958572105A5059552004 @default.
• W1958572105 hasAuthorship W1958572105A5066493053 @default.
• W1958572105 hasBestOaLocation W19585721051 @default.
• W1958572105 hasConcept C101762097 @default.
• W1958572105 hasConcept C104317684 @default.
• W1958572105 hasConcept C105580179 @default.
• W1958572105 hasConcept C114684123 @default.
• W1958572105 hasConcept C119056186 @default.
• W1958572105 hasConcept C134320426 @default.
• W1958572105 hasConcept C150194340 @default.
• W1958572105 hasConcept C153911025 @default.
• W1958572105 hasConcept C167672396 @default.
• W1958572105 hasConcept C179464577 @default.
• W1958572105 hasConcept C194583182 @default.
• W1958572105 hasConcept C22667442 @default.
• W1958572105 hasConcept C2776090121 @default.
• W1958572105 hasConcept C54355233 @default.
• W1958572105 hasConcept C54458228 @default.
• W1958572105 hasConcept C67705224 @default.
• W1958572105 hasConcept C86803240 @default.
• W1958572105 hasConcept C8891405 @default.
• W1958572105 hasConcept C89604277 @default.
• W1958572105 hasConcept C95444343 @default.
• W1958572105 hasConceptScore W1958572105C101762097 @default.
• W1958572105 hasConceptScore W1958572105C104317684 @default.
• W1958572105 hasConceptScore W1958572105C105580179 @default.
• W1958572105 hasConceptScore W1958572105C114684123 @default.
• W1958572105 hasConceptScore W1958572105C119056186 @default.
• W1958572105 hasConceptScore W1958572105C134320426 @default.
• W1958572105 hasConceptScore W1958572105C150194340 @default.
• W1958572105 hasConceptScore W1958572105C153911025 @default.
• W1958572105 hasConceptScore W1958572105C167672396 @default.
• W1958572105 hasConceptScore W1958572105C179464577 @default.
• W1958572105 hasConceptScore W1958572105C194583182 @default.
• W1958572105 hasConceptScore W1958572105C22667442 @default.

• next