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• W1958797869 startingPage "5497" @default.
• W1958797869 abstract "Abstract Coxsackievirus infection causes myocarditis and pancreatitis in humans. In certain strains of mice, Coxsackievirus causes a severe pancreatitis. We explored the role of NO in the host immune response to viral pancreatitis. Coxsackievirus replicates to higher titers in mice lacking NO synthase 2 (NOS2) than in wild-type mice, with particularly high viral titers and viral RNA levels in the pancreas. Mice lacking NOS have a severe, necrotizing pancreatitis, with elevated pancreatic enzymes in the blood and necrotic acinar cells. Lack of NOS2 leads to a rapid increase in the mortality of infected mice. Thus, NOS2 is a critical component in the immune response to Coxsackievirus infection." @default.
• W1958797869 created "2016-06-24" @default.
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• W1958797869 date "1999-11-15" @default.
• W1958797869 modified "2023-10-10" @default.
• W1958797869 title "Inducible Nitric Oxide Synthase Protection Against Coxsackievirus Pancreatitis" @default.
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• W1958797869 doi "https://doi.org/10.4049/jimmunol.163.10.5497" @default.
• W1958797869 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10553076" @default.
• W1958797869 hasPublicationYear "1999" @default.
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