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- W1958802014 abstract "We used event-related functional magnetic resonance imaging (fMRI) to measure brain activity when subjects were performing identical tasks in the context of either a task-set switch or a continuation of earlier performance. The context, i.e., switching or staying with the current task, influenced medial frontal cortical activation; the medial frontal cortex is transiently activated at the time that subjects switch from one way of performing a task to another. Two types of task-set-switching paradigms were investigated. In the response-switching (RS) paradigm, subjects switched between different rules for response selection and had to choose between competing responses. In the visual-switching (VS) paradigm, subjects switched between different rules for stimulus selection and had to choose between competing visual stimuli. The type of conflict, sensory (VS) or motor (RS), involved in switching was critical in determining medial frontal activation. Switching in the RS paradigm was associated with clear blood-oxygenation-level-dependent signal increases (“activations”) in three medial frontal areas: the rostral cingulate zone, the caudal cingulate zone, and the presupplementary motor area (pre-SMA). Switching in the VS task was associated with definite activation in just one medial frontal area, a region on the border between the pre-SMA and the SMA. Subsequent to the fMRI session, we used MRI-guided frameless stereotaxic procedures and repetitive transcranial magnetic stimulation (rTMS) to test the importance of the medial frontal activations for task switching. Applying rTMS over the pre-SMA disrupted subsequent RS performance but only when it was applied in the context of a switch. This result shows, first, that the pre-SMA is essential for task switching and second that its essential role is transient and limited to just the time of behavioral switching. The results are consistent with a role for the pre-SMA in selecting between response sets at a superordinate level rather than in selecting individual responses. The effect of the rTMS was not simply due to the tactile and auditory artifacts associated with each pulse; rTMS over several control regions did not selectively disrupt switching. Applying rTMS over the SMA/pre-SMA area activated in the VS paradigm did not disrupt switching. This result, first, confirms the limited importance of the medial frontal cortex for sensory attentional switching. Second, the VS rTMS results suggest that just because an area is activated in two paradigms does not mean that it plays the same essentialrole in both cases." @default.
- W1958802014 created "2016-06-24" @default.
- W1958802014 creator A5008874281 @default.
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- W1958802014 date "2002-05-01" @default.
- W1958802014 modified "2023-10-17" @default.
- W1958802014 title "Role of the Human Medial Frontal Cortex in Task Switching: A Combined fMRI and TMS Study" @default.
- W1958802014 cites W1488022817 @default.
- W1958802014 cites W1565967720 @default.
- W1958802014 cites W1583548689 @default.
- W1958802014 cites W1591367364 @default.
- W1958802014 cites W1659864209 @default.
- W1958802014 cites W1694363227 @default.
- W1958802014 cites W1800296272 @default.
- W1958802014 cites W1833341014 @default.
- W1958802014 cites W1859758524 @default.
- W1958802014 cites W1890309915 @default.
- W1958802014 cites W1894535096 @default.
- W1958802014 cites W1922121539 @default.
- W1958802014 cites W1948090175 @default.
- W1958802014 cites W1967279856 @default.
- W1958802014 cites W1975938737 @default.
- W1958802014 cites W1978135580 @default.
- W1958802014 cites W1978348414 @default.
- W1958802014 cites W1980557981 @default.
- W1958802014 cites W1981725931 @default.
- W1958802014 cites W1987599891 @default.
- W1958802014 cites W1989430061 @default.
- W1958802014 cites W1991434325 @default.
- W1958802014 cites W1992049705 @default.
- W1958802014 cites W1995412600 @default.
- W1958802014 cites W1996962636 @default.
- W1958802014 cites W1997774747 @default.
- W1958802014 cites W1999651610 @default.
- W1958802014 cites W2004996944 @default.
- W1958802014 cites W2013657375 @default.
- W1958802014 cites W2014200002 @default.
- W1958802014 cites W2021181097 @default.
- W1958802014 cites W2028197169 @default.
- W1958802014 cites W2036123029 @default.
- W1958802014 cites W2036444842 @default.
- W1958802014 cites W2037715202 @default.
- W1958802014 cites W2041702001 @default.
- W1958802014 cites W2043117568 @default.
- W1958802014 cites W2049430110 @default.
- W1958802014 cites W2050395086 @default.
- W1958802014 cites W2050751924 @default.
- W1958802014 cites W2053551529 @default.
- W1958802014 cites W2054662256 @default.
- W1958802014 cites W2057046889 @default.
- W1958802014 cites W2057598144 @default.
- W1958802014 cites W2058317558 @default.
- W1958802014 cites W2060012280 @default.
- W1958802014 cites W2067323852 @default.
- W1958802014 cites W2070137269 @default.
- W1958802014 cites W2070401011 @default.
- W1958802014 cites W2070952322 @default.
- W1958802014 cites W2071783141 @default.
- W1958802014 cites W2079204873 @default.
- W1958802014 cites W2081269553 @default.
- W1958802014 cites W2081653557 @default.
- W1958802014 cites W2089986839 @default.
- W1958802014 cites W2096184964 @default.
- W1958802014 cites W2106527356 @default.
- W1958802014 cites W2107751769 @default.
- W1958802014 cites W2109652963 @default.
- W1958802014 cites W2111105999 @default.
- W1958802014 cites W2114104729 @default.
- W1958802014 cites W2116881264 @default.
- W1958802014 cites W2120357670 @default.
- W1958802014 cites W2120476994 @default.
- W1958802014 cites W2125823313 @default.
- W1958802014 cites W2127888334 @default.
- W1958802014 cites W2128059165 @default.
- W1958802014 cites W2129291496 @default.
- W1958802014 cites W2134587483 @default.
- W1958802014 cites W2136299016 @default.
- W1958802014 cites W2138807694 @default.
- W1958802014 cites W2139027031 @default.
- W1958802014 cites W2141796362 @default.
- W1958802014 cites W2142106331 @default.
- W1958802014 cites W2144219890 @default.
- W1958802014 cites W2147886727 @default.
- W1958802014 cites W2148058251 @default.
- W1958802014 cites W2150323363 @default.
- W1958802014 cites W2150704745 @default.
- W1958802014 cites W2152250123 @default.
- W1958802014 cites W2154099072 @default.
- W1958802014 cites W2160226100 @default.
- W1958802014 cites W2160527423 @default.
- W1958802014 cites W2163759684 @default.
- W1958802014 cites W2165426881 @default.
- W1958802014 cites W2168293194 @default.
- W1958802014 cites W2171754727 @default.
- W1958802014 cites W2208113695 @default.
- W1958802014 cites W2212756896 @default.