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• W1958873030 abstract "Based on the adsorption between tetracycline (TC) and phosphate groups, a general colorimetric method is explored in this work by using TC-stabilized gold nanoparticles (TC/AuNPs) and 4-aminophenyl phosphate-functionalized Fe3O4 magnetic nanoparticles (APP/MNPs). Taking protein tyrosine phosphatase 1B (PTP1B) as an example, 4-aminophenyl phosphate (APP) can be hydrolyzed into 4-aminophenol (AP) by PTP1B, resulting in the disappearance of the phosphate group on the outer layer of MNPs and the loss of corresponding adsorptive ability. Upon addition of TC/AuNP solution, TC/AuNPs will remain in the supernatant solution after magnetic separation and a high absorbance value can be observed. So PTP1B activity is related to the concentrations of TC/AuNPs in the supernatant solution. In this work, the enzyme activity can be determined at levels as low as 0.0885 U mL(-1) and over a linear detection range as wide as 0.1 U mL(-1) to 0.9 U mL(-1). Moreover, using the proposed method, the inhibition effect of betulinic acid (BA) and sodium orthovanadate (Na3VO4) on PTP1B activity can be tested with IC50 values of 30 μM and 4 μM, respectively. Therefore, a universal platform for the accurate colorimetric analysis of kinase and phosphatase activities can be established through the adsorption between TC and phosphate groups." @default.
• W1958873030 created "2016-06-24" @default.
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• W1958873030 date "2015-01-01" @default.
• W1958873030 modified "2023-09-30" @default.
• W1958873030 title "Adsorption between TC-stabilized AuNPs and the phosphate group: application of the PTP1B activity assay" @default.
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• W1958873030 doi "https://doi.org/10.1039/c5an01906k" @default.
• W1958873030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26523458" @default.
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