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• W1959496920 abstract "Deutsch D, Silverstein N, Shilo D, Lecht S, Lazarovici P, Blumenfeld A. Biphasic influence of hypoxia on tuftelin expression in mouse mesenchymal C3H10T1/2 stem cells. Eur J Oral Sci 2011; 119 (Suppl. 1): 55–61. © 2011 Eur J Oral Sci Tuftelin, an acidic protein, thought to play a role in the initial stages of ectodermal enamel mineralization, has since been detected in mesenchymal‐derived tissues. During bone/cartilage development and regeneration, mesenchymal stem cells (MSCs) undergo an avascular period in a hypoxic environment, involving induction of hypoxia‐inducible factor 1‐alpha (HIF‐1‐alpha), a key component in this process. In the present study we investigated, in a mouse mesenchymal C3H10T1/2 stem cell model, the hypothesis that oxygen stress modulates tuftelin 1 expression in relation to HIF‐1‐alpha ( Hif1a ), in a mouse mesenchymal C3H10T1/2 stem cell model. The results of the present study showed a biphasic induction of tuftelin, similar to the pattern of HIF‐1‐alpha expression, in MSCs subjected to a hypoxic insult of 1% O 2 through a period of 2–24 h. Immunocytochemistry analysis of the cells exposed to hypoxic insult for 2–24 h revealed the same biphasic pattern of tuftelin protein expression. Tuftelin localization appears to be mainly in the cytoplasm, and concentrated at the perinuclear region of the cells by 24 h of hypoxic insult. Based on our previous studies using the neuronal PC12 cell model, in which tuftelin induction was mediated by Hif1a , we propose that tuftelin is a member of oxygen‐sensitive genes and implicated in the adaptive mechanisms regulating MSC function." @default.
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• W1959496920 date "2011-12-01" @default.
• W1959496920 modified "2023-10-03" @default.
• W1959496920 title "Biphasic influence of hypoxia on tuftelin expression in mouse mesenchymal C3H10T1/2 stem cells" @default.
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• W1959496920 doi "https://doi.org/10.1111/j.1600-0722.2011.00861.x" @default.
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