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- W195951916 abstract "Intraperitoneal chemotherapy has been used for gynecologic and gastrointestinal adenocarcinoma. This regional approach is considered in these diseases in which cancer spread to peritoneal surfaces is a prominent feature of the natural history. Limited benefits recorded with this route of drug delivery have been attributed to limited access of drug to cancer deposits. This occurs because of non-uniform drug distribution as a result of adhesions and because of limited penetration of drug into tumor nodules [1,2]. In an attempt to increase responses, we treated 24 patients with intraperitoneal chemotherapy prior to an extensive cytoreductive surgical procedure. Our hopes were that induction intraperitoneal chemotherapy would show improved results of treatment because there would be fewer adhesions than in the postoperative period. Also, it was hoped that induction chemotherapy would reduce the volume of intraabdominal cancer and thereby simplify the extensive cytoreductive surgery that may be required in patients with peritoneal carcinomatosis [3,4]. As a result of this clinical experience, a plan of management for patients with colonic or appendiceal cancer isolated to peritoneal surfaces has evolved." @default.
- W195951916 created "2016-06-24" @default.
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- W195951916 date "1996-01-01" @default.
- W195951916 modified "2023-09-27" @default.
- W195951916 title "Treatment of peritoneal carcinomatosis from colon or appendiceal cancer with induction intraperitoneal chemotherapy" @default.
- W195951916 cites W2168598108 @default.
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- W195951916 doi "https://doi.org/10.1007/978-1-4613-1247-5_20" @default.
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