FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1959638470> ?p ?o ?g. }

• W1959638470 endingPage "335" @default.
• W1959638470 startingPage "328" @default.
• W1959638470 abstract "Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that has been demonstrated to regulate the apoptosis of several cell types. Dysregulated apoptosis of fibroblasts has been implicated in a variety of fibrotic diseases, including systemic sclerosis (SSc). In this study, we investigated the role of MIF in the apoptosis of dermal fibroblasts. The concentrations of MIF were measured in sera and in culture supernatants of peripheral blood mononuclear cells (PBMCs) and dermal fibroblasts by enzyme-linked immunosorbent assay. The degree of apoptosis was determined by colorimetric assay, and signalling pathways were examined by Western blot. The results showed that serum levels of MIF were significantly higher in patients with SSc (n = 47) than in healthy controls (n = 56). Stimulation of PBMCs by anti-CD3 and anti-CD28 increased the production of MIF by fourfold over the constitutive levels. SSc dermal fibroblasts produced higher amounts of MIF than normal dermal fibroblasts. When treated with sodium nitroprusside (SNP), SSc dermal fibroblasts showed a lower degree of apoptosis compared with normal dermal fibroblasts. Exogenous MIF (1-100 ng/ml) inhibited SNP-induced apoptosis of dermal fibroblasts dose-dependently. Both extracellular regulated kinase (ERK) inhibitor (PD98059) and protein kinase B (Akt) inhibitor (LY294002) almost completely blocked the inhibitory effect of MIF on apoptosis. Furthermore, MIF increased the expression of Bcl-2, phospho-ERK and phospho-Akt activity in dermal fibroblasts. Taken together, our data suggest that MIF released by activated T cells and dermal fibroblasts decreases the apoptosis of dermal fibroblasts through activation of ERK, Akt and Bcl-2 signalling pathways, which might be associated with excessive fibrosis in SSc." @default.
• W1959638470 created "2016-06-24" @default.
• W1959638470 creator A5013840350 @default.
• W1959638470 creator A5016732313 @default.
• W1959638470 creator A5038398861 @default.
• W1959638470 creator A5047895958 @default.
• W1959638470 creator A5053593042 @default.
• W1959638470 creator A5061867704 @default.
• W1959638470 creator A5070502354 @default.
• W1959638470 creator A5071454819 @default.
• W1959638470 date "2008-03-19" @default.
• W1959638470 modified "2023-10-14" @default.
• W1959638470 title "Up-regulated macrophage migration inhibitory factor protects apoptosis of dermal fibroblasts in patients with systemic sclerosis" @default.
• W1959638470 cites W1913068299 @default.
• W1959638470 cites W1971944674 @default.
• W1959638470 cites W1975290731 @default.
• W1959638470 cites W19803778 @default.
• W1959638470 cites W1986837253 @default.
• W1959638470 cites W1987445277 @default.
• W1959638470 cites W1989832114 @default.
• W1959638470 cites W1989947080 @default.
• W1959638470 cites W1990145914 @default.
• W1959638470 cites W1996353231 @default.
• W1959638470 cites W1996489151 @default.
• W1959638470 cites W2001634895 @default.
• W1959638470 cites W2002535617 @default.
• W1959638470 cites W2006937273 @default.
• W1959638470 cites W2007510904 @default.
• W1959638470 cites W2010042266 @default.
• W1959638470 cites W2012103481 @default.
• W1959638470 cites W2028921539 @default.
• W1959638470 cites W2029459007 @default.
• W1959638470 cites W2034055171 @default.
• W1959638470 cites W2042343908 @default.
• W1959638470 cites W2044771066 @default.
• W1959638470 cites W2045309790 @default.
• W1959638470 cites W2049310294 @default.
• W1959638470 cites W2057418352 @default.
• W1959638470 cites W2058645214 @default.
• W1959638470 cites W2063739726 @default.
• W1959638470 cites W2065907626 @default.
• W1959638470 cites W2077008732 @default.
• W1959638470 cites W2078458274 @default.
• W1959638470 cites W2085330118 @default.
• W1959638470 cites W2087676487 @default.
• W1959638470 cites W2096619153 @default.
• W1959638470 cites W2101348176 @default.
• W1959638470 cites W2101996270 @default.
• W1959638470 cites W2105073777 @default.
• W1959638470 cites W2110929110 @default.
• W1959638470 cites W2112781735 @default.
• W1959638470 cites W2115279208 @default.
• W1959638470 cites W2121697121 @default.
• W1959638470 cites W2146058212 @default.
• W1959638470 cites W2163820586 @default.
• W1959638470 cites W4253944988 @default.
• W1959638470 cites W7405620 @default.
• W1959638470 doi "https://doi.org/10.1111/j.1365-2249.2008.03637.x" @default.
• W1959638470 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2384108" @default.
• W1959638470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18355352" @default.
• W1959638470 hasPublicationYear "2008" @default.
• W1959638470 type Work @default.
• W1959638470 sameAs 1959638470 @default.
• W1959638470 citedByCount "22" @default.
• W1959638470 countsByYear W19596384702013 @default.
• W1959638470 countsByYear W19596384702014 @default.
• W1959638470 countsByYear W19596384702015 @default.
• W1959638470 countsByYear W19596384702016 @default.
• W1959638470 countsByYear W19596384702017 @default.
• W1959638470 countsByYear W19596384702018 @default.
• W1959638470 countsByYear W19596384702019 @default.
• W1959638470 countsByYear W19596384702020 @default.
• W1959638470 countsByYear W19596384702021 @default.
• W1959638470 crossrefType "journal-article" @default.
• W1959638470 hasAuthorship W1959638470A5013840350 @default.
• W1959638470 hasAuthorship W1959638470A5016732313 @default.
• W1959638470 hasAuthorship W1959638470A5038398861 @default.
• W1959638470 hasAuthorship W1959638470A5047895958 @default.
• W1959638470 hasAuthorship W1959638470A5053593042 @default.
• W1959638470 hasAuthorship W1959638470A5061867704 @default.
• W1959638470 hasAuthorship W1959638470A5070502354 @default.
• W1959638470 hasAuthorship W1959638470A5071454819 @default.
• W1959638470 hasBestOaLocation W19596384701 @default.
• W1959638470 hasConcept C104177226 @default.
• W1959638470 hasConcept C137061746 @default.
• W1959638470 hasConcept C153911025 @default.
• W1959638470 hasConcept C164027704 @default.
• W1959638470 hasConcept C184235292 @default.
• W1959638470 hasConcept C185592680 @default.
• W1959638470 hasConcept C190283241 @default.
• W1959638470 hasConcept C202751555 @default.
• W1959638470 hasConcept C203014093 @default.
• W1959638470 hasConcept C2776914184 @default.
• W1959638470 hasConcept C2778005187 @default.
• W1959638470 hasConcept C2778690821 @default.
• W1959638470 hasConcept C2780381497 @default.
• W1959638470 hasConcept C502942594 @default.
• W1959638470 hasConcept C54355233 @default.

• next