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- W1959772169 abstract "Siglecs are a family of sialic acid-recognizing immunoglobulin-like lectins that exhibit multiple human-specific and human-universal differences, including changes in binding specificity (Siglec-5, -7, -9, -11, -12 and 14); changes in expression pattern (Siglec-1, -5, -6, and -11); gene conversion (SIGLEC11); gene deletion (SIGLEC13) and pseudogenization (SIGLEC17). Human-unique pseudogenes of SIGLEC12, SIGLEC14 and SIGLEC16 are also polymorphic within human populations, suggesting ongoing selection on this family of genes. The apparently higher concentration of SIGLEC changes in the human lineage may have been selected by interactions with pathogens binding Siglecs, and/or as compensatory responses to the loss of the sialic acid N-glycolylneuraminic acid (Neu5Gc) in humans. Human-specific Siglec changes of particular interest include expression of Siglec-11 in brain microglia, expression of Siglec-6 on placental trophoblast, suppression of Siglec-5 expression on adaptive immune cells, new expression of Siglec-5 on amniotic epithelium, and elimination of Siglec-13 and -17 from innate immune cells. The Siglec-13 and -17 inactivation events fixed in the ancestral population shortly before the common ancestor of modern humans 100–200 thousand years ago, and resurrected Siglec-13 and -17 gene products bind potentially lethal pathogens of infants. While such pathogens may have contributed to population bottlenecks in human evolution, the resulting changes in sialic acid biology may also have altered multiple systems where sialic acid and Siglecs have endogenous roles. Thus, genes associated with sialic acid biology appear to be a “hot spot” of genetic and physiological change during human evolution, with implications for human origins, and for uniquely human features in health and disease." @default.
- W1959772169 created "2016-06-24" @default.
- W1959772169 creator A5022305308 @default.
- W1959772169 creator A5036413821 @default.
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- W1959772169 date "2014-11-03" @default.
- W1959772169 modified "2023-10-10" @default.
- W1959772169 title "Human-Specific Evolutionary Changes in the Biology of Siglecs" @default.
- W1959772169 cites W1527781812 @default.
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- W1959772169 cites W16780934 @default.
- W1959772169 cites W1809465031 @default.
- W1959772169 cites W1838963185 @default.
- W1959772169 cites W1964344178 @default.
- W1959772169 cites W1966930760 @default.
- W1959772169 cites W1967724223 @default.
- W1959772169 cites W1968858193 @default.
- W1959772169 cites W1971907885 @default.
- W1959772169 cites W1974517970 @default.
- W1959772169 cites W1976722506 @default.
- W1959772169 cites W1995691857 @default.
- W1959772169 cites W2004207764 @default.
- W1959772169 cites W2011571944 @default.
- W1959772169 cites W2011986522 @default.
- W1959772169 cites W2018805974 @default.
- W1959772169 cites W2019062483 @default.
- W1959772169 cites W2019986705 @default.
- W1959772169 cites W2028439746 @default.
- W1959772169 cites W2028672566 @default.
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- W1959772169 cites W2059450339 @default.
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- W1959772169 cites W2065134483 @default.
- W1959772169 cites W2067911388 @default.
- W1959772169 cites W2074405990 @default.
- W1959772169 cites W2075620204 @default.
- W1959772169 cites W2075853683 @default.
- W1959772169 cites W2080302351 @default.
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- W1959772169 doi "https://doi.org/10.1007/978-3-319-11280-0_1" @default.
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