FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1959884270> ?p ?o ?g. }

• W1959884270 endingPage "e125" @default.
• W1959884270 startingPage "e120" @default.
• W1959884270 abstract "In chronic hepatitis C (CHC), treatment duration may be individualized according to time to first undetectable hepatitis C virus (HCV) RNA, with patients who attain undetectable HCV RNA early in treatment being candidates for shorter regimens. The aim of this study was to determine the relapse rate in patients with CHC genotype (G) 1 infection and low baseline viral load who achieved undetectable HCV RNA by week 4 [rapid virologic response (RVR)] when treated for 24 weeks. This was an open-label, multicentre, noninterventional study. Adult patients with G1 CHC infection and baseline viral load <600,000 IU/mL who attained RVR were treated with peginterferon alfa-2b (1.5 μg/kg/week) plus ribavirin (800-1200 mg/day) for 24 weeks, then followed for a further 24 weeks. The primary endpoint was relapse rate, defined as the proportion of patients with undetectable HCV RNA at treatment week 24 and detectable HCV RNA at week 24 follow-up. The secondary efficacy endpoint was sustained virologic response (SVR). Overall, 170 patients were included in the efficacy-evaluable population. The relapse rate was 9.7% (16/165, 95% confidence interval: 0.06-0.15), and SVR was attained by 149 of 170 patients (87.6%). Virologic outcomes were consistent regardless of age, gender, body weight and genotype. Seven patients reported treatment-emergent serious adverse events (AEs), and four patients discontinued treatment because of an AE. This study further demonstrates that peginterferon alfa-2b plus weight-based ribavirin for 24 weeks is an effective treatment strategy for treatment-naive patients with G1 CHC and low viral load who attain RVR." @default.
• W1959884270 created "2016-06-24" @default.
• W1959884270 creator A5001733670 @default.
• W1959884270 creator A5001838803 @default.
• W1959884270 creator A5009270009 @default.
• W1959884270 creator A5024908454 @default.
• W1959884270 creator A5027225143 @default.
• W1959884270 creator A5032082926 @default.
• W1959884270 creator A5038247507 @default.
• W1959884270 creator A5039554874 @default.
• W1959884270 creator A5041520897 @default.
• W1959884270 creator A5045084738 @default.
• W1959884270 creator A5059809028 @default.
• W1959884270 creator A5061689613 @default.
• W1959884270 creator A5067805804 @default.
• W1959884270 creator A5071063920 @default.
• W1959884270 date "2011-09-19" @default.
• W1959884270 modified "2023-09-30" @default.
• W1959884270 title "Peginterferon alfa-2b plus weight-based ribavirin for 24 weeks in patients with chronic hepatitis C virus genotype 1 with low viral load who achieve rapid viral response" @default.
• W1959884270 cites W1970734373 @default.
• W1959884270 cites W1980850694 @default.
• W1959884270 cites W1983585538 @default.
• W1959884270 cites W2024043429 @default.
• W1959884270 cites W2027912196 @default.
• W1959884270 cites W2034654277 @default.
• W1959884270 cites W2039345617 @default.
• W1959884270 cites W2057177770 @default.
• W1959884270 cites W2060988847 @default.
• W1959884270 cites W2063859957 @default.
• W1959884270 cites W2068329523 @default.
• W1959884270 cites W2075282196 @default.
• W1959884270 cites W2112876622 @default.
• W1959884270 cites W2127685726 @default.
• W1959884270 cites W2153921667 @default.
• W1959884270 doi "https://doi.org/10.1111/j.1365-2893.2011.01515.x" @default.
• W1959884270 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22239509" @default.
• W1959884270 hasPublicationYear "2011" @default.
• W1959884270 type Work @default.
• W1959884270 sameAs 1959884270 @default.
• W1959884270 citedByCount "5" @default.
• W1959884270 countsByYear W19598842702013 @default.
• W1959884270 countsByYear W19598842702014 @default.
• W1959884270 countsByYear W19598842702015 @default.
• W1959884270 crossrefType "journal-article" @default.
• W1959884270 hasAuthorship W1959884270A5001733670 @default.
• W1959884270 hasAuthorship W1959884270A5001838803 @default.
• W1959884270 hasAuthorship W1959884270A5009270009 @default.
• W1959884270 hasAuthorship W1959884270A5024908454 @default.
• W1959884270 hasAuthorship W1959884270A5027225143 @default.
• W1959884270 hasAuthorship W1959884270A5032082926 @default.
• W1959884270 hasAuthorship W1959884270A5038247507 @default.
• W1959884270 hasAuthorship W1959884270A5039554874 @default.
• W1959884270 hasAuthorship W1959884270A5041520897 @default.
• W1959884270 hasAuthorship W1959884270A5045084738 @default.
• W1959884270 hasAuthorship W1959884270A5059809028 @default.
• W1959884270 hasAuthorship W1959884270A5061689613 @default.
• W1959884270 hasAuthorship W1959884270A5067805804 @default.
• W1959884270 hasAuthorship W1959884270A5071063920 @default.
• W1959884270 hasBestOaLocation W19598842702 @default.
• W1959884270 hasConcept C126322002 @default.
• W1959884270 hasConcept C142462285 @default.
• W1959884270 hasConcept C168563851 @default.
• W1959884270 hasConcept C197934379 @default.
• W1959884270 hasConcept C203014093 @default.
• W1959884270 hasConcept C203092338 @default.
• W1959884270 hasConcept C2522874641 @default.
• W1959884270 hasConcept C2776235749 @default.
• W1959884270 hasConcept C2776408679 @default.
• W1959884270 hasConcept C2776455275 @default.
• W1959884270 hasConcept C2780040827 @default.
• W1959884270 hasConcept C2908647359 @default.
• W1959884270 hasConcept C71924100 @default.
• W1959884270 hasConcept C90924648 @default.
• W1959884270 hasConcept C99454951 @default.
• W1959884270 hasConceptScore W1959884270C126322002 @default.
• W1959884270 hasConceptScore W1959884270C142462285 @default.
• W1959884270 hasConceptScore W1959884270C168563851 @default.
• W1959884270 hasConceptScore W1959884270C197934379 @default.
• W1959884270 hasConceptScore W1959884270C203014093 @default.
• W1959884270 hasConceptScore W1959884270C203092338 @default.
• W1959884270 hasConceptScore W1959884270C2522874641 @default.
• W1959884270 hasConceptScore W1959884270C2776235749 @default.
• W1959884270 hasConceptScore W1959884270C2776408679 @default.
• W1959884270 hasConceptScore W1959884270C2776455275 @default.
• W1959884270 hasConceptScore W1959884270C2780040827 @default.
• W1959884270 hasConceptScore W1959884270C2908647359 @default.
• W1959884270 hasConceptScore W1959884270C71924100 @default.
• W1959884270 hasConceptScore W1959884270C90924648 @default.
• W1959884270 hasConceptScore W1959884270C99454951 @default.
• W1959884270 hasIssue "2" @default.
• W1959884270 hasLocation W19598842701 @default.
• W1959884270 hasLocation W19598842702 @default.
• W1959884270 hasLocation W19598842703 @default.
• W1959884270 hasOpenAccess W1959884270 @default.
• W1959884270 hasPrimaryLocation W19598842701 @default.
• W1959884270 hasRelatedWork W180129732 @default.
• W1959884270 hasRelatedWork W1959884270 @default.
• W1959884270 hasRelatedWork W1970047932 @default.

• next