Matches in SemOpenAlex for { <https://semopenalex.org/work/W1959888979> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W1959888979 abstract "Disturbance in the vitamin D/parathyroid hormone (PTH) axis may be important in the pathogenesis of glucose intolerance and insulin resistance in uraemia. To investigate possible relationships between hyperparathyroidism, intracellular free calcium ([Ca2+]i), and glucose tolerance in chronic renal failure, we measured serum intact PTH (I-PTH) by two-site immunometric assay, platelet [Ca2+]i using the fluorescent indicator fura-2, and plasma glucose and insulin after 14 h overnight fast and at 30, 60 and 120 min following a 75 g oral glucose load, in 18 chronic haemodialysis patients with elevated serum I-PTH. Calcitriol (1 microgram) was administered parenterally at the end of each dialysis session for four weeks. This significantly decreased serum I-PTH (p < 0.001) and platelet [Ca2+]i (p < 0.01). Uraemic patients initially showed marked glucose intolerance, with increased area below the glucose curve compared to healthy controls, but after 4 weeks of calcitriol treatment, this effect was significantly decreased, and there was a significant rise in the area under the insulin curve after glucose load. The insulinogenic index also increased significantly after calcitriol treatment. These data suggest that calcitriol treatment of haemodialysis patient with secondary hyperparathyroidism is associated with increased insulin secretion in response to glucose challenge, and that this change is linked to the decrease in intracellular free calcium." @default.
- W1959888979 created "2016-06-24" @default.
- W1959888979 creator A5006277848 @default.
- W1959888979 creator A5016470107 @default.
- W1959888979 creator A5020442958 @default.
- W1959888979 creator A5027812322 @default.
- W1959888979 creator A5030035068 @default.
- W1959888979 creator A5047798771 @default.
- W1959888979 creator A5052036844 @default.
- W1959888979 creator A5068113586 @default.
- W1959888979 creator A5068873897 @default.
- W1959888979 date "1994-06-01" @default.
- W1959888979 modified "2023-09-28" @default.
- W1959888979 title "Hyperparathyroidism, glucose tolerance and platelet intracellular free calcium in chronic renal failure" @default.
- W1959888979 doi "https://doi.org/10.1093/oxfordjournals.qjmed.a068941" @default.
- W1959888979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8041868" @default.
- W1959888979 hasPublicationYear "1994" @default.
- W1959888979 type Work @default.
- W1959888979 sameAs 1959888979 @default.
- W1959888979 citedByCount "6" @default.
- W1959888979 countsByYear W19598889792014 @default.
- W1959888979 countsByYear W19598889792015 @default.
- W1959888979 countsByYear W19598889792016 @default.
- W1959888979 crossrefType "journal-article" @default.
- W1959888979 hasAuthorship W1959888979A5006277848 @default.
- W1959888979 hasAuthorship W1959888979A5016470107 @default.
- W1959888979 hasAuthorship W1959888979A5020442958 @default.
- W1959888979 hasAuthorship W1959888979A5027812322 @default.
- W1959888979 hasAuthorship W1959888979A5030035068 @default.
- W1959888979 hasAuthorship W1959888979A5047798771 @default.
- W1959888979 hasAuthorship W1959888979A5052036844 @default.
- W1959888979 hasAuthorship W1959888979A5068113586 @default.
- W1959888979 hasAuthorship W1959888979A5068873897 @default.
- W1959888979 hasConcept C126322002 @default.
- W1959888979 hasConcept C134018914 @default.
- W1959888979 hasConcept C2775945674 @default.
- W1959888979 hasConcept C2776079296 @default.
- W1959888979 hasConcept C2778838027 @default.
- W1959888979 hasConcept C2779306644 @default.
- W1959888979 hasConcept C2781208988 @default.
- W1959888979 hasConcept C519063684 @default.
- W1959888979 hasConcept C71924100 @default.
- W1959888979 hasConceptScore W1959888979C126322002 @default.
- W1959888979 hasConceptScore W1959888979C134018914 @default.
- W1959888979 hasConceptScore W1959888979C2775945674 @default.
- W1959888979 hasConceptScore W1959888979C2776079296 @default.
- W1959888979 hasConceptScore W1959888979C2778838027 @default.
- W1959888979 hasConceptScore W1959888979C2779306644 @default.
- W1959888979 hasConceptScore W1959888979C2781208988 @default.
- W1959888979 hasConceptScore W1959888979C519063684 @default.
- W1959888979 hasConceptScore W1959888979C71924100 @default.
- W1959888979 hasLocation W19598889791 @default.
- W1959888979 hasLocation W19598889792 @default.
- W1959888979 hasOpenAccess W1959888979 @default.
- W1959888979 hasPrimaryLocation W19598889791 @default.
- W1959888979 hasRelatedWork W1959888979 @default.
- W1959888979 hasRelatedWork W1973274158 @default.
- W1959888979 hasRelatedWork W2005957842 @default.
- W1959888979 hasRelatedWork W2129739601 @default.
- W1959888979 hasRelatedWork W2147487489 @default.
- W1959888979 hasRelatedWork W2161501577 @default.
- W1959888979 hasRelatedWork W2165283016 @default.
- W1959888979 hasRelatedWork W2213868530 @default.
- W1959888979 hasRelatedWork W2279623030 @default.
- W1959888979 hasRelatedWork W2416442364 @default.
- W1959888979 isParatext "false" @default.
- W1959888979 isRetracted "false" @default.
- W1959888979 magId "1959888979" @default.
- W1959888979 workType "article" @default.