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• W1960097149 abstract "Lactoferrin (Lf), a multifunctional glycoprotein, is known to activate dermal fibroblasts. Enhancing percutaneous absorption without decreasing the activity of Lf is critical in making the dermal administration of Lf beneficial. Sophorolipid (SL), a glycolipid-type biosurfactant, is known to form assemblies that may elevate the efficiency of the transdermal delivery of active ingredients. Here, we investigated the role of SL in the transdermal absorption of bovine Lf (bLf) and the effect of SL on the bLf activity on dermal fibroblasts. Transdermal absorption of bLf through a model skin was enhanced by 1.3-fold to 1.7-fold when SL was added. The effects of SL on the bLf activities on dermal fibroblasts were examined by cell proliferation activities and by gene expression levels of elastic fiber components, collagen IV, and hyaluronan synthases, revealing that SL did not depress the effect of bLf to any extent. Instead, the tropoelastin gene expression was upregulated ∼60-fold by bLf alone, which was further increased to ∼160-fold by bLf and SL together, suggesting a significant synergism between bLf and SL. Protein levels of elastin, assessed by immunohistochemistry, correlated well with the results of gene expressions. These results indicate the feasibility of the transdermal administration of bLf with SL." @default.
• W1960097149 created "2016-06-24" @default.
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• W1960097149 date "2012-06-01" @default.
• W1960097149 modified "2023-09-25" @default.
• W1960097149 title "Transdermal administration of lactoferrin with sophorolipid¹This article is part of a Special Issue entitled Lactoferrin and has undergone the Journal's usual peer review process." @default.
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• W1960097149 doi "https://doi.org/10.1139/o11-065" @default.
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